180176

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 188417..188939 Replicon plasmid unnamed2
Accession NZ_CP064110
Organism Klebsiella oxytoca strain IR5392

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag ISU85_RS29365 Protein ID WP_004181778.1
Coordinates 188655..188939 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag ISU85_RS29360 Protein ID WP_025368601.1
Coordinates 188417..188665 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU85_RS29340 183626..184447 - 822 WP_004026535.1 hypothetical protein -
ISU85_RS29345 184509..184862 - 354 WP_004181774.1 hypothetical protein -
ISU85_RS29350 185007..185993 - 987 WP_025368599.1 hypothetical protein -
ISU85_RS29355 186327..188126 - 1800 WP_025368600.1 ATP-dependent helicase -
ISU85_RS29360 188417..188665 + 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ISU85_RS29365 188655..188939 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISU85_RS29370 189169..190395 + 1227 WP_025368602.1 transposase -
ISU85_RS29375 190681..191106 - 426 WP_040120489.1 IS200/IS605 family transposase -
ISU85_RS29380 191143..192369 + 1227 WP_025368604.1 transposase -
ISU85_RS29385 192435..193561 - 1127 Protein_200 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..223677 223677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T180176 WP_004181778.1 NZ_CP064110:188655-188939 [Klebsiella oxytoca]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T180176 NZ_CP085080:c4096096-4095605 [Enterobacter cloacae]
ATGATCTCTGCCCCAGAACCCCTTCACGCCGGTCATATTCTTACTCCATTTTGCTGTGGTGTGGATTCGATGGATAACTG
GCTGAAGCAGCGGGCGATGAAAAATCAGGTCAGTGGTGCATCCCGTACCTTTGTCTGTTGTGGCAACGATTCTAACGTTC
TGGCTTATTACTCGCTGGCATCCAGCGCGGTCATGACGAATACCGCACCCGGTCGCTTTCGTCGCAATATGCCCGATCCC
ATCCCGGTTGTTGTGCTGGGACGCCTGGCGGTAGATCAGTCTCTGCATGGGCAGGGCGTTGGTCGGGCACTGGTACGCGA
CGCTGGGCTGCGGGTGATCCAGGTGGCGGAGACCATCGGCATTCGCGGAATGCTGGTTCATGCGCTGTCGGATGAAGCGC
GGGAATTTTATCTGCGGGTGGGGTTTGAGCCATCGCCAATGGATCCGATGATATTGATGGTGACGTTGGGGGATTTGATG
GCGAATATTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT180176 WP_025368601.1 NZ_CP064110:188417-188665 [Klebsiella oxytoca]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT180176 NZ_CP085080:c4096386-4096093 [Enterobacter cloacae]
ATGCCAGCTGCAAACACTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAGGCCTGCCGAGCGAGATCTTATCGA
TCGGGCGGCGAAAGCGAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCAGCCCGCGCTGCTGCGGAAGAGGCACTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAATTTCTGGCTCGTCTGGATCAGGCTCCAGCACCTAAT
GCCACACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAGCGGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References