Detailed information of TA system TA180172

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 5081142..5081961
• Replicon: chromosome
• Accession: NZ_CP064108
• Organism: Klebsiella oxytoca strain IR5392

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: ISU85_RS24030
• Protein ID: WP_004110819.1
• Coordinates: 5081704..5081961 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: ISU85_RS24025
• Protein ID: WP_023320373.1
• Coordinates: 5081142..5081693 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISU85_RS24005	5076521..5077201	+	681	WP_023320375.1	nitroreductase	-
ISU85_RS24010	5077209..5078411	-	1203	WP_023320374.1	multidrug effflux MFS transporter	-
ISU85_RS24015	5079117..5079368	-	252	WP_004110826.1	hypothetical protein	-
ISU85_RS24020	5079496..5081124	-	1629	WP_004110824.1	SAM-dependent methyltransferase	-
ISU85_RS24025	5081142..5081693	-	552	WP_023320373.1	N-acetyltransferase	Antitoxin
ISU85_RS24030	5081704..5081961	-	258	WP_004110819.1	YjhX family toxin	Toxin
ISU85_RS24035	5082543..5083727	+	1185	WP_004099225.1	mannonate dehydratase	-
ISU85_RS24040	5083802..5085277	+	1476	WP_004110817.1	fructuronate reductase	-
ISU85_RS24045	5085413..5086189	+	777	WP_004099223.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (17-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T180172 WP_004110819.1 NZ_CP064108:c5081961-5081704 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T180172 NZ_CP085080:c1154951-1154733 [Enterobacter cloacae]
ATGTCTGATAAACCACTCACAAAAACCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACACTCGAACGCGT
GATTGAAAAAAATAAATACGAGCTTTCTGATAATGAACTGACCGTATTTTATTCAGCCGCTGACCATCGCCTTGCCGAGC
TGACCATGAATAAACTGTATGACAAAATCCCGCCTTCCGTGTGGAAATTTGTCCGTTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20138.98 Da
• Isoelectric Point: 6.8799

>AT180172 WP_023320373.1 NZ_CP064108:c5081693-5081142 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVAALLNDESAHPSLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGVGVGGLLIQRGIEHLKAAGSEAVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT180172 NZ_CP085080:c1155353-1154979 [Enterobacter cloacae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAATCATGGCTGGGTGAACGATCCAACATCGGCCATCAATTTGCAATTGAATGAGTTGATAGAGC
ATATCGCGACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAACTGATTGAGCAAATTGACGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCGCAGGATTTGCAGAAATGGCGTAAATCTGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2