Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4856601..4857220 Replicon chromosome
Accession NZ_CP064108
Organism Klebsiella oxytoca strain IR5392

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag ISU85_RS22970 Protein ID WP_004099646.1
Coordinates 4857002..4857220 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag ISU85_RS22965 Protein ID WP_004099648.1
Coordinates 4856601..4856975 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU85_RS22955 4851757..4852950 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ISU85_RS22960 4852973..4856119 + 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit -
ISU85_RS22965 4856601..4856975 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
ISU85_RS22970 4857002..4857220 + 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
ISU85_RS22975 4857381..4857947 + 567 WP_023320460.1 maltose O-acetyltransferase -
ISU85_RS22980 4858084..4858554 + 471 WP_004111038.1 YlaC family protein -
ISU85_RS22985 4858529..4859983 - 1455 WP_023320459.1 PLP-dependent aminotransferase family protein -
ISU85_RS22990 4860085..4860783 + 699 WP_004099639.1 GNAT family N-acetyltransferase -
ISU85_RS22995 4860780..4860920 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
ISU85_RS23000 4860920..4861183 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T180171 WP_004099646.1 NZ_CP064108:4857002-4857220 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T180171 NZ_CP085080:645649-645936 [Enterobacter cloacae]
ATGCCAACGGAGTATGAGTGGGATAGCGATAAGGCGAAAAGTAACCAGCAAAAACATGGCATACGCTTTGAGGATGCGGT
TCTGGTTTTCGACGATCCTTATCATTTGTCTGTTCAGGATCGCTATGAGAACGGTGAGTTTCGCTGGCAAACCATCGGCC
TTGTGCAAGGCGTCATTGTTATCCTGGTCGCACATACGGTACGTTTCGAAAGCGGAGGCGAAATTATTCGTATCATTAGC
GCACGTAAGGCGGACCGTAAAGAGAGGAACCGTTATGAGCATCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT180171 WP_004099648.1 NZ_CP064108:4856601-4856975 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT180171 NZ_CP085080:645923-646225 [Enterobacter cloacae]
ATGAGCATCGTTAAACATAAACGAGGTAGTTCGCCTGAGGTTAGCGCTCGTCGTGACGCTGAGCTAAAAGCATTAGCTGA
AAAACCAGAAGCAGAAATCGATTACAGCGATATTCCTGCCACGGACGATAAACAGTGGTCCGGGGCGGTGCGAGGGAAGT
TCTATCGGCCACTTAAAACGCAGGCATCTGTACGCATTGACGCCGACGTGATGGAGTGGCTAAAACGGCCTGGAAAGGGT
TACCAGACGCGGCTAAACGCCATATTGCGTGAAGCGATGCTGCGCGATCAAAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References