Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1259484..1260141 Replicon chromosome
Accession NZ_CP064108
Organism Klebsiella oxytoca strain IR5392

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag ISU85_RS05980 Protein ID WP_004105559.1
Coordinates 1259731..1260141 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag ISU85_RS05975 Protein ID WP_004105561.1
Coordinates 1259484..1259750 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU85_RS05960 1254737..1255162 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
ISU85_RS05965 1255283..1258081 - 2799 WP_023321613.1 transcriptional regulator DagR -
ISU85_RS05970 1258257..1259240 - 984 WP_004115279.1 tRNA-modifying protein YgfZ -
ISU85_RS05975 1259484..1259750 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
ISU85_RS05980 1259731..1260141 + 411 WP_004105559.1 protein YgfX Toxin
ISU85_RS05985 1260150..1260671 - 522 WP_004105557.1 flavodoxin FldB -
ISU85_RS05990 1260793..1261689 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
ISU85_RS05995 1261712..1262425 + 714 WP_023321612.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISU85_RS06000 1262431..1264164 + 1734 WP_004105553.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T180161 WP_004105559.1 NZ_CP064108:1259731-1260141 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

>T180161 NZ_CP085074:c4443299-4443126 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT180161 WP_004105561.1 NZ_CP064108:1259484-1259750 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT180161 NZ_CP085074:c4443623-4443327 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References