Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 38931..39478 Replicon plasmid unnamed4
Accession NZ_CP064107
Organism Escherichia coli strain IR53017

Toxin (Protein)


Gene name parE Uniprot ID A0A896ZGX1
Locus tag ISU84_RS27400 Protein ID WP_000969997.1
Coordinates 38931..39212 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E0WH52
Locus tag ISU84_RS27405 Protein ID WP_000079932.1
Coordinates 39209..39478 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU84_RS27380 34932..36278 - 1347 WP_001132021.1 hypothetical protein -
ISU84_RS27385 36632..37225 + 594 WP_001401779.1 hypothetical protein -
ISU84_RS27390 37507..38094 - 588 WP_001418189.1 serine acetyltransferase -
ISU84_RS27395 38394..38735 + 342 WP_000578011.1 hypothetical protein -
ISU84_RS27400 38931..39212 - 282 WP_000969997.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISU84_RS27405 39209..39478 - 270 WP_000079932.1 hypothetical protein Antitoxin
ISU84_RS27410 39533..39691 - 159 WP_000829588.1 hypothetical protein -
ISU84_RS27415 40386..41258 - 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
ISU84_RS27420 41961..42602 + 642 WP_021515453.1 hypothetical protein -
ISU84_RS27425 42742..43404 + 663 WP_005082527.1 hypothetical protein -
ISU84_RS27430 43671..43814 + 144 WP_000176500.1 hypothetical protein -
ISU84_RS27435 43895..44137 + 243 WP_021515452.1 PilI type IV pilus biogenesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid erm(B) - 1..86173 86173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10879.54 Da        Isoelectric Point: 8.4615

>T180160 WP_000969997.1 NZ_CP064107:c39212-38931 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YVLRVLHTAQKWP

Download         Length: 282 bp

>T180160 NZ_CP085074:c4341130-4340780 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10268.58 Da        Isoelectric Point: 7.2055

>AT180160 WP_000079932.1 NZ_CP064107:c39478-39209 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVSDK

Download         Length: 270 bp

>AT180160 NZ_CP085074:c4341375-4341124 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A896ZGX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5U8RN22

References