Detailed information of TA system TA180147

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4848495..4849483
• Replicon: chromosome
• Accession: NZ_CP064103
• Organism: Escherichia coli strain IR53017

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: ISU84_RS23505
• Protein ID: WP_014640052.1
• Coordinates: 4848495..4848881 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0A1AFM1
• Locus tag: ISU84_RS23510
• Protein ID: WP_000458583.1
• Coordinates: 4848911..4849483 (-)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISU84_RS23470	4844060..4844260	-	201	WP_021527487.1	helix-turn-helix domain-containing protein	-
ISU84_RS23475	4844351..4845025	+	675	WP_021530636.1	LexA family transcriptional regulator	-
ISU84_RS23480	4845693..4846055	+	363	WP_000135680.1	hypothetical protein	-
ISU84_RS23485	4846121..4846945	+	825	WP_023908886.1	DUF2303 family protein	-
ISU84_RS23490	4847164..4847916	+	753	WP_024946495.1	hypothetical protein	-
ISU84_RS23495	4847953..4848234	+	282	WP_001093916.1	pyocin activator PrtN family protein	-
ISU84_RS23500	4848282..4848455	-	174	WP_023908888.1	hypothetical protein	-
ISU84_RS23505	4848495..4848881	-	387	WP_014640052.1	hypothetical protein	Toxin
ISU84_RS23510	4848911..4849483	-	573	WP_000458583.1	SocA family protein	Antitoxin
ISU84_RS23515	4849719..4849841	-	123	WP_001300034.1	hypothetical protein	-
ISU84_RS23520	4850203..4851207	-	1005	WP_022646425.1	DUF2713 family protein	-
ISU84_RS23525	4851525..4852040	+	516	WP_000416263.1	zinc uptake transcriptional repressor Zur	-
ISU84_RS23530	4852082..4852291	-	210	WP_001296638.1	CsbD family protein	-
ISU84_RS23535	4852407..4853732	-	1326	WP_001361471.1	MATE family efflux transporter DinF	-
ISU84_RS23540	4853805..4854413	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4809782..4854891	45109

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T180147 WP_014640052.1 NZ_CP064103:c4848881-4848495 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T180147 NZ_CP085074:1115564-1115899 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21956.30 Da
• Isoelectric Point: 6.0283

>AT180147 WP_000458583.1 NZ_CP064103:c4849483-4848911 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT180147 NZ_CP085074:1115316-1115564 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0A1AFM1