Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3405563..3406268 Replicon chromosome
Accession NZ_CP064103
Organism Escherichia coli strain IR53017

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag ISU84_RS16265 Protein ID WP_000539521.1
Coordinates 3405563..3405949 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ISU84_RS16270 Protein ID WP_001280945.1
Coordinates 3405939..3406268 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU84_RS16245 3401566..3402192 + 627 WP_001295292.1 glutathione S-transferase GstB -
ISU84_RS16250 3402189..3403304 - 1116 WP_000554964.1 aldose sugar dehydrogenase YliI -
ISU84_RS16255 3403415..3403798 - 384 WP_000497137.1 biofilm formation regulator BssR -
ISU84_RS16260 3404012..3405337 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
ISU84_RS16265 3405563..3405949 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISU84_RS16270 3405939..3406268 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
ISU84_RS16275 3406338..3407666 - 1329 WP_022645414.1 GGDEF domain-containing protein -
ISU84_RS16280 3407674..3410022 - 2349 WP_022645413.1 EAL domain-containing protein -
ISU84_RS16285 3410199..3411110 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T180139 WP_000539521.1 NZ_CP064103:3405563-3405949 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T180139 NZ_CP085071:c43638-43486 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT180139 WP_001280945.1 NZ_CP064103:3405939-3406268 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT180139 NZ_CP085071:43690-43750 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References