Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 925886..926684 Replicon chromosome
Accession NZ_CP064103
Organism Escherichia coli strain IR53017

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag ISU84_RS04410 Protein ID WP_000854735.1
Coordinates 925886..926263 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag ISU84_RS04415 Protein ID WP_001285415.1
Coordinates 926310..926684 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU84_RS04380 921854..923119 - 1266 WP_001218869.1 integrase arm-type DNA-binding domain-containing protein -
ISU84_RS04385 923583..923909 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU84_RS04390 923906..924169 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
ISU84_RS04395 924241..925107 - 867 WP_001280433.1 DUF4942 domain-containing protein -
ISU84_RS04400 925192..925389 - 198 WP_000839291.1 DUF957 domain-containing protein -
ISU84_RS04405 925401..925889 - 489 WP_000761676.1 hypothetical protein -
ISU84_RS04410 925886..926263 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
ISU84_RS04415 926310..926684 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ISU84_RS04420 926764..926985 - 222 WP_000692309.1 DUF987 domain-containing protein -
ISU84_RS04425 927048..927524 - 477 WP_001366855.1 RadC family protein -
ISU84_RS04430 927540..928025 - 486 WP_206356552.1 antirestriction protein -
ISU84_RS04435 928117..928935 - 819 WP_001175175.1 DUF945 domain-containing protein -
ISU84_RS04440 929025..929234 - 210 WP_032150870.1 DUF905 family protein -
ISU84_RS04445 929264..929941 - 678 WP_001097301.1 hypothetical protein -
ISU84_RS04450 930089..930769 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / papX / papI 716853..956287 239434


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T180126 WP_000854735.1 NZ_CP064103:c926263-925886 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T180126 NZ_CP085069:2817210-2817317 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT180126 WP_001285415.1 NZ_CP064103:c926684-926310 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT180126 NZ_CP085069:c2817162-2817095 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References