Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
Location | 610029..610945 | Replicon | chromosome |
Accession | NZ_CP064095 | ||
Organism | Bacillus subtilis strain N1303-2Ay |
Toxin (Protein)
Gene name | spoIISA | Uniprot ID | O34853 |
Locus tag | IRJ27_RS02855 | Protein ID | WP_003244695.1 |
Coordinates | 610029..610775 (+) | Length | 249 a.a. |
Antitoxin (Protein)
Gene name | spoIISB | Uniprot ID | G4EXD8 |
Locus tag | IRJ27_RS02860 | Protein ID | WP_003232646.1 |
Coordinates | 610775..610945 (+) | Length | 57 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IRJ27_RS02830 (605110) | 605110..605256 | - | 147 | WP_003244977.1 | hypothetical protein | - |
IRJ27_RS02835 (605357) | 605357..606307 | - | 951 | WP_003245086.1 | ring-cleaving dioxygenase | - |
IRJ27_RS02840 (606696) | 606696..608012 | + | 1317 | WP_003244819.1 | serine/threonine exchanger | - |
IRJ27_RS02845 (608288) | 608288..608905 | + | 618 | WP_003218470.1 | DUF47 domain-containing protein | - |
IRJ27_RS02850 (608918) | 608918..609919 | + | 1002 | WP_003232642.1 | inorganic phosphate transporter | - |
IRJ27_RS02855 (610029) | 610029..610775 | + | 747 | WP_003244695.1 | toxin-antitoxin-antitoxin system toxin SpoIISA | Toxin |
IRJ27_RS02860 (610775) | 610775..610945 | + | 171 | WP_003232646.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISB | Antitoxin |
IRJ27_RS02865 (611031) | 611031..611168 | + | 138 | WP_003232648.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISC | - |
IRJ27_RS02870 (611205) | 611205..612098 | - | 894 | WP_003245230.1 | N-acetylmuramoyl-L-alanine amidase | - |
IRJ27_RS02875 (612111) | 612111..612374 | - | 264 | WP_003232653.1 | phage holin | - |
IRJ27_RS02880 (612387) | 612387..612656 | - | 270 | WP_003232655.1 | hemolysin XhlA family protein | - |
IRJ27_RS02885 (612709) | 612709..613548 | - | 840 | WP_003245597.1 | phage-like element PBSX protein XepA | - |
IRJ27_RS02890 (613592) | 613592..613756 | - | 165 | WP_003232658.1 | XkdX family protein | - |
IRJ27_RS02895 (613753) | 613753..614082 | - | 330 | WP_003232660.1 | XkdW family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29061.50 Da Isoelectric Point: 4.6191
>T180076 WP_003244695.1 NZ_CP064095:610029-610775 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
Download Length: 747 bp
>T180076 NZ_CP085060:c4452348-4452241 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6654.72 Da Isoelectric Point: 11.0203
>AT180076 WP_003232646.1 NZ_CP064095:610775-610945 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
Download Length: 171 bp
>AT180076 NZ_CP085060:4452396-4452462 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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