Detailed information of TA system TA180022

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 8809..9343
• Replicon: plasmid p1
• Accession: NZ_CP064064
• Organism: Brucella anthropi strain PBO

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IR196_RS22785
• Protein ID: WP_194532023.1
• Coordinates: 9047..9343 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: IR196_RS22780
• Protein ID: WP_194532022.1
• Coordinates: 8809..9057 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IR196_RS22755	4415..5371	+	957	WP_194532018.1	DMT family transporter	-
IR196_RS22760	5922..6134	+	213	WP_194532019.1	ribbon-helix-helix domain-containing protein	-
IR196_RS22765	6326..7204	+	879	WP_194532020.1	helix-turn-helix domain-containing protein	-
IR196_RS22770	7703..8362	+	660	WP_194532021.1	AAA family ATPase	-
IR196_RS22775	8359..8697	+	339	WP_194532030.1	chromosome partitioning protein ParB	-
IR196_RS22780	8809..9057	+	249	WP_194532022.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
IR196_RS22785	9047..9343	+	297	WP_194532023.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IR196_RS22790	9378..9601	+	224	Protein_13	hypothetical protein	-
IR196_RS22795	10027..10429	-	403	Protein_14	hypothetical protein	-
IR196_RS22800	10503..10712	-	210	WP_194532024.1	hypothetical protein	-
IR196_RS22805	10717..11001	-	285	WP_194532025.1	mobilization protein	-
IR196_RS22810	10982..11230	-	249	WP_194532026.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..27634	27634

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-93)

Antitoxin

• Antitoxin ParD (3-78)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11423.15 Da
• Isoelectric Point: 10.8343

>T180022 WP_194532023.1 NZ_CP064064:9047-9343 [Brucella anthropi]
MATKRPFRLAPAAKADLRKIWRYTARRWSLEQAETYQDQLYAAFEGLAAGTKKGRDVDVRRGYLKYPAGSHIVYFKDRGD
RIEIIRVLHGRMDASRHL

Nucleotide

• Length: 297 bp

>T180022 NZ_CP084987:c337684-337202 [Klebsiella pneumoniae]
GTGGGACGTTTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTGGCTGAGTTCGTCAGCGGTGAGGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCCCTCGGAGCTGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGCAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGCGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCAGCGAACATTGTTTCTTAGACTCCCT
TAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8910.82 Da
• Isoelectric Point: 4.4098

>AT180022 WP_194532022.1 NZ_CP064064:8809-9057 [Brucella anthropi]
MAARSTSISLGDHFAGFIDSQVQTGRYGSVSDVVRAGLRLLEEHEAKVKALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GH

Nucleotide

• Length: 249 bp

>AT180022 NZ_CP084987:c337959-337672 [Klebsiella pneumoniae]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAATGGCCTGTCAGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGCGGAGTTCATCGACATGCTTGATGCACCTGTCGTAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTTTAA