Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 3339085..3339614 Replicon chromosome
Accession NZ_CP064057
Organism Streptomyces sp. XC 2026

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IPZ77_RS15115 Protein ID WP_200366167.1
Coordinates 3339357..3339614 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IPZ77_RS15110 Protein ID WP_200366166.1
Coordinates 3339085..3339360 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPZ77_RS15080 3335595..3336302 - 708 WP_200366159.1 hypothetical protein -
IPZ77_RS15085 3336523..3337083 - 561 WP_200366161.1 hypothetical protein -
IPZ77_RS15090 3337199..3337711 - 513 WP_200368648.1 hypothetical protein -
IPZ77_RS15095 3337766..3337879 - 114 WP_200366163.1 hypothetical protein -
IPZ77_RS15100 3337972..3338394 - 423 WP_200366165.1 PIN domain nuclease -
IPZ77_RS15105 3338391..3338606 - 216 WP_023548893.1 type II toxin-antitoxin system VapB family antitoxin -
IPZ77_RS15110 3339085..3339360 + 276 WP_200366166.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IPZ77_RS15115 3339357..3339614 + 258 WP_200366167.1 Txe/YoeB family addiction module toxin Toxin
IPZ77_RS15130 3340141..3342221 + 2081 Protein_2987 DNA polymerase III subunit gamma and tau -
IPZ77_RS15135 3342302..3342646 + 345 WP_078635678.1 YbaB/EbfC family nucleoid-associated protein -
IPZ77_RS15140 3342735..3343334 + 600 WP_030735527.1 recombination mediator RecR -
IPZ77_RS15145 3343368..3344087 + 720 WP_030735523.1 DUF5063 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10073.54 Da        Isoelectric Point: 9.9563

>T180018 WP_200366167.1 NZ_CP064057:3339357-3339614 [Streptomyces sp. XC 2026]
VRNVDLDPAAWDDFLFWLASDRKTARRITRLIAEVQRTPFEGIGKPEPLKGDLTGYWSRRINDEHRLVCRTGDKEMKIIK
ARYHY

Download         Length: 258 bp

>T180018 NZ_CP084986:c4772517-4772233 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10001.14 Da        Isoelectric Point: 4.4978

>AT180018 WP_200366166.1 NZ_CP064057:3339085-3339360 [Streptomyces sp. XC 2026]
MSISASEARKSLFPLIERVNTDHDPVRITSKAGDAVLMSADDYDSWQETIYFLRSPANAQRLMEAVARDKAGEAGAARTL
DELRNMAGAEE

Download         Length: 276 bp

>AT180018 NZ_CP084986:c4772749-4772507 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References