Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 897932..898458 Replicon chromosome
Accession NZ_CP064056
Organism Staphylococcus lloydii strain 23_2_7_LY

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ISP08_RS04260 Protein ID WP_048793380.1
Coordinates 898102..898458 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ISP08_RS04255 Protein ID WP_195719517.1
Coordinates 897932..898102 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISP08_RS04230 893768..894247 + 480 WP_195719521.1 PH domain-containing protein -
ISP08_RS04235 894240..895733 + 1494 WP_195719520.1 PH domain-containing protein -
ISP08_RS04240 895726..896196 + 471 WP_195719519.1 PH domain-containing protein -
ISP08_RS04245 896237..896590 + 354 WP_195719518.1 holo-ACP synthase -
ISP08_RS04250 896697..897845 + 1149 WP_048793378.1 alanine racemase -
ISP08_RS04255 897932..898102 + 171 WP_195719517.1 antitoxin MazE Antitoxin
ISP08_RS04260 898102..898458 + 357 WP_048793380.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ISP08_RS04265 898718..899719 + 1002 WP_195719516.1 PP2C family protein-serine/threonine phosphatase -
ISP08_RS04270 899800..900126 + 327 WP_048793382.1 anti-sigma factor antagonist -
ISP08_RS04275 900128..900607 + 480 WP_195719570.1 anti-sigma B factor RsbW -
ISP08_RS04280 900582..901352 + 771 WP_048793384.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13348.51 Da        Isoelectric Point: 10.2885

>T180017 WP_048793380.1 NZ_CP064056:898102-898458 [Staphylococcus lloydii]
MRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
LDKKRLKEKLTYLSEDKMKEVNNALDISLGLHNVRNHK

Download         Length: 357 bp

>T180017 NZ_CP084986:c4670673-4670140 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6242.68 Da        Isoelectric Point: 3.8099

>AT180017 WP_195719517.1 NZ_CP064056:897932-898102 [Staphylococcus lloydii]
MSSFNQSRNHNIEQSLKEGYSQMADLNLSLAAEAFPFECEACDCNESYISSNNTSD

Download         Length: 171 bp

>AT180017 NZ_CP084986:c4670950-4670684 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References