Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 887044..887557 Replicon chromosome
Accession NZ_CP064056
Organism Staphylococcus lloydii strain 23_2_7_LY

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag ISP08_RS04200 Protein ID WP_195719525.1
Coordinates 887351..887557 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag ISP08_RS04195 Protein ID WP_048793368.1
Coordinates 887044..887337 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISP08_RS04170 882311..883099 + 789 WP_195719571.1 hydroxyethylthiazole kinase -
ISP08_RS04175 883103..883732 + 630 WP_195719529.1 thiamine phosphate synthase -
ISP08_RS04180 883829..884695 + 867 WP_195719528.1 membrane protein insertase YidC -
ISP08_RS04185 884759..885400 - 642 WP_195719527.1 HD domain-containing protein -
ISP08_RS04190 885420..886904 - 1485 WP_195719526.1 cardiolipin synthase -
ISP08_RS04195 887044..887337 + 294 WP_048793368.1 copper-sensing transcriptional repressor CsoR Antitoxin
ISP08_RS04200 887351..887557 + 207 WP_195719525.1 heavy-metal-associated domain-containing protein Toxin
ISP08_RS04205 887695..887835 + 141 WP_103295720.1 hypothetical protein -
ISP08_RS04210 887882..889099 - 1218 WP_195719524.1 rod shape-determining protein RodA -
ISP08_RS04215 889361..890431 + 1071 WP_195719523.1 D-alanine--D-alanine ligase -
ISP08_RS04220 890444..891799 + 1356 WP_195719522.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7473.48 Da        Isoelectric Point: 4.7540

>T180016 WP_195719525.1 NZ_CP064056:887351-887557 [Staphylococcus lloydii]
MVTKVILVAGLNTAEQAESLTQHLLNIIGVHQANVDSQNSSIQVTFTTPANLNNIEKEIYDKGYTIIF

Download         Length: 207 bp

>T180016 NZ_CP084986:4057852-4058070 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11088.67 Da        Isoelectric Point: 6.4770

>AT180016 WP_048793368.1 NZ_CP064056:887044-887337 [Staphylococcus lloydii]
MTEVSQAHHSTQTKNNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMEKIDNGEN
EAAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT180016 NZ_CP084986:4057451-4057825 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References