180015

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3912476..3913293 Replicon chromosome
Accession NZ_CP064055
Organism Morganella morganii subsp. morganii strain GN28

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag IR219_RS18670 Protein ID WP_015422406.1
Coordinates 3912476..3912982 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag IR219_RS18675 Protein ID WP_032097998.1
Coordinates 3912985..3913293 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR219_RS18635 (IR219_18635) 3907835..3908458 - 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -
IR219_RS18640 (IR219_18640) 3908477..3909472 - 996 WP_048821883.1 serine/threonine protein kinase -
IR219_RS18645 (IR219_18645) 3909472..3909741 - 270 WP_036415677.1 YihD family protein -
IR219_RS19705 3909962..3910534 + 573 Protein_3632 molybdenum cofactor guanylyltransferase MobA -
IR219_RS19710 3910541..3911059 + 519 WP_223302449.1 molybdopterin-guanine dinucleotide biosynthesis protein MobB -
IR219_RS18655 (IR219_18655) 3911274..3911576 + 303 WP_004240743.1 HdeA/HdeB family chaperone -
IR219_RS18660 (IR219_18660) 3911704..3912225 + 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
IR219_RS18665 3912222..3912362 + 141 WP_004236531.1 hypothetical protein -
IR219_RS18670 (IR219_18670) 3912476..3912982 - 507 WP_015422406.1 GNAT family N-acetyltransferase Toxin
IR219_RS18675 (IR219_18675) 3912985..3913293 - 309 WP_032097998.1 DUF1778 domain-containing protein Antitoxin
IR219_RS18680 (IR219_18680) 3913425..3914777 - 1353 WP_032098064.1 glutathione-disulfide reductase -
IR219_RS18685 (IR219_18685) 3914846..3915688 - 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
IR219_RS18690 (IR219_18690) 3915878..3916267 + 390 WP_004236536.1 DUF1090 domain-containing protein -
IR219_RS18695 (IR219_18695) 3916679..3917671 + 993 WP_032098000.1 inner membrane protein YhjD -
IR219_RS18700 (IR219_18700) 3917779..3917985 + 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-143)

Antitoxin

Vibrio phage ICP1, Orf50

(21-94)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18565.43 Da        Isoelectric Point: 9.9508

>T180015 WP_015422406.1 NZ_CP064055:c3912982-3912476 [Morganella morganii subsp. morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE

Download         Length: 507 bp

>T180015 NZ_CP084986:c2710704-2709382 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11469.12 Da        Isoelectric Point: 8.6397

>AT180015 WP_032097998.1 NZ_CP064055:c3913293-3912985 [Morganella morganii subsp. morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLAKAPWEK

Download         Length: 309 bp

>AT180015 NZ_CP084986:c2710970-2710704 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References