Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1048622..1049248 Replicon chromosome
Accession NZ_CP064055
Organism Morganella morganii subsp. morganii strain GN28

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag IR219_RS04915 Protein ID WP_158691283.1
Coordinates 1048622..1048825 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag IR219_RS04920 Protein ID WP_004236473.1
Coordinates 1048889..1049248 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR219_RS04895 (IR219_04895) 1045178..1045516 + 339 WP_004236467.1 P-II family nitrogen regulator -
IR219_RS04900 (IR219_04900) 1045536..1046825 + 1290 WP_036422539.1 ammonium transporter AmtB -
IR219_RS04905 (IR219_04905) 1046886..1047749 - 864 WP_004240378.1 acyl-CoA thioesterase II -
IR219_RS04915 (IR219_04915) 1048622..1048825 - 204 WP_158691283.1 HHA domain-containing protein Toxin
IR219_RS04920 (IR219_04920) 1048889..1049248 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
IR219_RS04925 (IR219_04925) 1049811..1052987 - 3177 WP_004240375.1 efflux RND transporter permease subunit -
IR219_RS04930 (IR219_04930) 1053002..1054198 - 1197 WP_015422955.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8072.41 Da        Isoelectric Point: 7.9892

>T180014 WP_158691283.1 NZ_CP064055:c1048825-1048622 [Morganella morganii subsp. morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAANHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T180014 NZ_CP084986:1980409-1980511 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT180014 WP_004236473.1 NZ_CP064055:c1049248-1048889 [Morganella morganii subsp. morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT180014 NZ_CP084986:c1980518-1980373 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References