Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 3927833..3928650 | Replicon | chromosome |
| Accession | NZ_CP064054 | ||
| Organism | Morganella morganii subsp. morganii strain 516602 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | - |
| Locus tag | IR216_RS19170 | Protein ID | WP_015422406.1 |
| Coordinates | 3927833..3928339 (-) | Length | 169 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | J7TDK6 |
| Locus tag | IR216_RS19175 | Protein ID | WP_004236533.1 |
| Coordinates | 3928342..3928650 (-) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IR216_RS19135 (IR216_19150) | 3923197..3923820 | - | 624 | WP_004236525.1 | thiol:disulfide interchange protein DsbA | - |
| IR216_RS19140 (IR216_19155) | 3923839..3924834 | - | 996 | WP_004236526.1 | serine/threonine protein kinase | - |
| IR216_RS19145 (IR216_19160) | 3924834..3925103 | - | 270 | WP_004240741.1 | YihD family protein | - |
| IR216_RS20365 | 3925324..3925896 | + | 573 | Protein_3730 | molybdenum cofactor guanylyltransferase MobA | - |
| IR216_RS20370 | 3925903..3926421 | + | 519 | WP_225806429.1 | molybdopterin-guanine dinucleotide biosynthesis protein MobB | - |
| IR216_RS19155 (IR216_19170) | 3926631..3926933 | + | 303 | WP_004236529.1 | HdeA/HdeB family chaperone | - |
| IR216_RS19160 (IR216_19175) | 3927061..3927582 | + | 522 | WP_015422407.1 | isopentenyl-diphosphate Delta-isomerase | - |
| IR216_RS19165 | 3927579..3927719 | + | 141 | WP_004236531.1 | hypothetical protein | - |
| IR216_RS19170 (IR216_19185) | 3927833..3928339 | - | 507 | WP_015422406.1 | GNAT family N-acetyltransferase | Toxin |
| IR216_RS19175 (IR216_19190) | 3928342..3928650 | - | 309 | WP_004236533.1 | DUF1778 domain-containing protein | Antitoxin |
| IR216_RS19180 (IR216_19195) | 3928782..3930134 | - | 1353 | WP_004236534.1 | glutathione-disulfide reductase | - |
| IR216_RS19185 (IR216_19200) | 3930204..3931046 | - | 843 | WP_004236535.1 | 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ | - |
| IR216_RS19190 (IR216_19205) | 3931236..3931625 | + | 390 | WP_004236536.1 | DUF1090 domain-containing protein | - |
| IR216_RS19195 (IR216_19210) | 3932037..3933029 | + | 993 | WP_004236539.1 | inner membrane protein YhjD | - |
| IR216_RS19200 (IR216_19215) | 3933137..3933343 | + | 207 | WP_004236540.1 | 4-oxalocrotonate tautomerase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 169 a.a. Molecular weight: 18565.43 Da Isoelectric Point: 9.9508
>T180013 WP_015422406.1 NZ_CP064054:c3928339-3927833 [Morganella morganii subsp. morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE
Download Length: 507 bp
>T180013 NZ_CP084986:871041-871451 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11499.15 Da Isoelectric Point: 8.6397
>AT180013 WP_004236533.1 NZ_CP064054:c3928650-3928342 [Morganella morganii subsp. morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK
Download Length: 309 bp
>AT180013 NZ_CP084986:870794-871060 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|