Detailed information of TA system TA180012

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 905476..905959
• Replicon: chromosome
• Accession: NZ_CP064054
• Organism: Morganella morganii subsp. morganii strain 516602

Toxin (Protein)

• Gene name: relE
• Uniprot ID: J7TMG3
• Locus tag: IR216_RS04105
• Protein ID: WP_004237651.1
• Coordinates: 905732..905959 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IR216_RS04100
• Protein ID: WP_015422945.1
• Coordinates: 905476..905748 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IR216_RS04095 (IR216_04095)	900633..905267	+	4635	WP_004237649.1	hemagglutinin repeat-containing protein	-
IR216_RS04100 (IR216_04100)	905476..905748	+	273	WP_015422945.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IR216_RS04105 (IR216_04105)	905732..905959	+	228	WP_004237651.1	type II toxin-antitoxin system YafQ family toxin	Toxin
IR216_RS04110 (IR216_04110)	906262..907746	+	1485	WP_004237652.1	C69 family dipeptidase	-
IR216_RS04115 (IR216_04115)	907812..908264	-	453	WP_004237653.1	NfeD family protein	-
IR216_RS04120 (IR216_04120)	908261..909199	-	939	WP_004237654.1	SPFH domain-containing protein	-
IR216_RS04125 (IR216_04125)	909255..910112	-	858	WP_015422944.1	co-chaperone YbbN	-
IR216_RS04130 (IR216_04130)	910172..910957	-	786	WP_004241009.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-74)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-78)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 9069.63 Da
• Isoelectric Point: 9.9416

>T180012 WP_004237651.1 NZ_CP064054:905732-905959 [Morganella morganii subsp. morganii]
MARTIERSSQFKKDYKREVKGIYRMMLNDSLQNILNILVNDLPIPEKYADHPLKGNWRTFRDCHLYPDLILIYKK

Nucleotide

• Length: 228 bp

>T180012 NZ_CP084986:736778-737263 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10091.70 Da
• Isoelectric Point: 5.1746

>AT180012 WP_015422945.1 NZ_CP064054:905476-905748 [Morganella morganii subsp. morganii]
VEYVRAKIDPKLKAEAIETLESMGLTVSDAIRMLMIQIVEQKAMPFCVKSTQYRHAARTRAAIEELECGKGKKFDSISDL
MADLQDGKDD

Nucleotide

• Length: 273 bp

>AT180012 NZ_CP084986:736488-736781 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Toxin

• AlphaFold DB: J7TMG3