Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 1510468..1511121 | Replicon | chromosome |
| Accession | NZ_CP064048 | ||
| Organism | Anoxybacillus sediminis strain PCH 117 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | J2PLP3 |
| Locus tag | IRT44_RS07400 | Protein ID | WP_005830205.1 |
| Coordinates | 1510771..1511121 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | IRT44_RS07395 | Protein ID | WP_171566177.1 |
| Coordinates | 1510468..1510767 (+) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IRT44_RS07365 (IRT44_07305) | 1506006..1506257 | - | 252 | WP_171566169.1 | glutaredoxin family protein | - |
| IRT44_RS07370 (IRT44_07310) | 1506485..1506649 | + | 165 | WP_171566170.1 | gamma-type small acid-soluble spore protein | - |
| IRT44_RS07375 (IRT44_07315) | 1506772..1507158 | + | 387 | WP_171566171.1 | holo-ACP synthase | - |
| IRT44_RS07380 (IRT44_07320) | 1507400..1508434 | + | 1035 | WP_171566173.1 | DUF4367 domain-containing protein | - |
| IRT44_RS07385 (IRT44_07325) | 1508642..1509082 | + | 441 | WP_171566174.1 | hypothetical protein | - |
| IRT44_RS07390 (IRT44_07330) | 1509091..1510296 | + | 1206 | WP_171566176.1 | alanine racemase | - |
| IRT44_RS07395 (IRT44_07335) | 1510468..1510767 | + | 300 | WP_171566177.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| IRT44_RS07400 (IRT44_07340) | 1510771..1511121 | + | 351 | WP_005830205.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| IRT44_RS07405 (IRT44_07345) | 1511290..1511721 | + | 432 | WP_230077681.1 | anti-sigma regulatory factor | - |
| IRT44_RS07410 (IRT44_07350) | 1511718..1512719 | + | 1002 | WP_171566178.1 | PP2C family protein-serine/threonine phosphatase | - |
| IRT44_RS07415 (IRT44_07355) | 1512745..1513098 | + | 354 | WP_171566180.1 | anti-sigma factor antagonist | - |
| IRT44_RS07420 (IRT44_07360) | 1513071..1513562 | + | 492 | WP_171566182.1 | anti-sigma B factor RsbW | - |
| IRT44_RS07425 (IRT44_07365) | 1513531..1514313 | + | 783 | WP_171566184.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12917.86 Da Isoelectric Point: 4.8435
>T180003 WP_005830205.1 NZ_CP064048:1510771-1511121 [Anoxybacillus sediminis]
VIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVNESLQISLGLIDF
VIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVNESLQISLGLIDF
Download Length: 351 bp
>T180003 NZ_CP084984:c4696174-4695641 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11344.32 Da Isoelectric Point: 10.3594
>AT180003 WP_171566177.1 NZ_CP064048:1510468-1510767 [Anoxybacillus sediminis]
MVGGGFVLSKSNTKRIMISLPHHLLQEVDGVIQKEKSNRSEFIRQAMHLYLKERKKRVIRETMQKGYMEMAKINLKMASE
AFGAEEEADHTLIRLVSGV
MVGGGFVLSKSNTKRIMISLPHHLLQEVDGVIQKEKSNRSEFIRQAMHLYLKERKKRVIRETMQKGYMEMAKINLKMASE
AFGAEEEADHTLIRLVSGV
Download Length: 300 bp
>AT180003 NZ_CP084984:c4696451-4696185 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|