Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3172625..3173282 Replicon chromosome
Accession NZ_CP064046
Organism Klebsiella quasipneumoniae strain S15-2

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag IOD54_RS15470 Protein ID WP_004205323.1
Coordinates 3172625..3173035 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IOD54_RS15475 Protein ID WP_002916312.1
Coordinates 3173016..3173282 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD54_RS15450 3168625..3170358 - 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -
IOD54_RS15455 3170364..3171077 - 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IOD54_RS15460 3171100..3171996 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IOD54_RS15465 3172097..3172618 + 522 WP_004205324.1 flavodoxin FldB -
IOD54_RS15470 3172625..3173035 - 411 WP_004205323.1 protein YgfX Toxin
IOD54_RS15475 3173016..3173282 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IOD54_RS15480 3173528..3174511 + 984 WP_122542307.1 tRNA-modifying protein YgfZ -
IOD54_RS15485 3174610..3175269 - 660 WP_004205319.1 hemolysin III family protein -
IOD54_RS15490 3175432..3175743 - 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
IOD54_RS15495 3175793..3176521 + 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
IOD54_RS15500 3176640..3178073 + 1434 WP_049004121.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T179999 WP_004205323.1 NZ_CP064046:c3173035-3172625 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179999 NZ_CP084984:1468845-1469327 [Klebsiella pneumoniae]
GTGGGACGTGTAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTTGA
TGAATGGCTAAAGCACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAACTACAGGCAGACTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCCGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179999 WP_002916312.1 NZ_CP064046:c3173282-3173016 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179999 NZ_CP084984:1468591-1468857 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCTTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References