Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 5248696..5249315 Replicon chromosome
Accession NZ_CP064044
Organism Klebsiella quasipneumoniae strain BM404-3-1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag ISA72_RS25445 Protein ID WP_002892050.1
Coordinates 5248696..5248914 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag ISA72_RS25450 Protein ID WP_002892066.1
Coordinates 5248941..5249315 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA72_RS25410 5244739..5245002 + 264 WP_004204754.1 type B 50S ribosomal protein L31 -
ISA72_RS25415 5245002..5245142 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
ISA72_RS25420 5245139..5245837 - 699 WP_004204753.1 GNAT family N-acetyltransferase -
ISA72_RS25425 5245938..5247395 + 1458 WP_064178013.1 PLP-dependent aminotransferase family protein -
ISA72_RS25430 5247364..5247834 - 471 WP_004204751.1 YlaC family protein -
ISA72_RS25435 5247877..5247999 + 123 WP_032426076.1 hypothetical protein -
ISA72_RS25440 5247971..5248537 - 567 WP_004204750.1 maltose O-acetyltransferase -
ISA72_RS25445 5248696..5248914 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
ISA72_RS25450 5248941..5249315 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
ISA72_RS25455 5249800..5252946 - 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit -
ISA72_RS25460 5252969..5254162 - 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T179988 WP_002892050.1 NZ_CP064044:c5248914-5248696 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T179988 NZ_CP084924:c38958-38671 [Acinetobacter pittii]
ATGACCTATAAGTTAGACTTTTTAGAAGAAGCATTAGCAGAATGGAAAAAGCTTAATCCAAGTATTAAGCAACCATTGAA
GAAGAAACTGATCAAGGTACTAGAGAATCCTCGCATTCCCAAGAATAAGCTCCCAGGACATCCTAACCGCTACAAGATCA
AACTTCGCAGTGTTGGTTATCGTTTGGTTTATGAAGTGATTGATGATGAGGTTATTTTCATCGTCATTGCCGTAGGCAGA
CGTGAAAACAATGCTGTGTATGATGAAGCCAACTCTCGACATTCATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT179988 WP_002892066.1 NZ_CP064044:c5249315-5248941 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT179988 NZ_CP084924:c39196-38948 [Acinetobacter pittii]
ATGACTCAATTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCGATGGATACAGTGTTAGCAGG
TAAAGGTGAACCTGTAGCGATCCTTAATCGTAATATACCAGCGTTTTACTGTGTTCCGGCTGATTTGTATGAAACCATGA
TGGAACAACTGGAAGACCTGGAACTCAACAAAATTGCAGATGCTCGTGCGAATCAAAAACGCATTCGAGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References