Detailed information of TA system TA179987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4533759..4534272
• Replicon: chromosome
• Accession: NZ_CP064044
• Organism: Klebsiella quasipneumoniae strain BM404-3-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A663BE04
• Locus tag: ISA72_RS22115
• Protein ID: WP_017900571.1
• Coordinates: 4533991..4534272 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ISA72_RS22110
• Protein ID: WP_048322784.1
• Coordinates: 4533759..4534001 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISA72_RS22095	4529691..4530431	+	741	WP_004206507.1	KDGP aldolase family protein	-
ISA72_RS22100	4530594..4531748	+	1155	WP_065697356.1	lactonase family protein	-
ISA72_RS22105	4531771..4533681	+	1911	WP_004206509.1	BglG family transcription antiterminator	-
ISA72_RS22110	4533759..4534001	+	243	WP_048322784.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ISA72_RS22115	4533991..4534272	+	282	WP_017900571.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ISA72_RS22120	4534276..4534740	-	465	WP_023319597.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
ISA72_RS22125	4535123..4537261	-	2139	WP_080838453.1	anaerobic ribonucleoside-triphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11082.93 Da
• Isoelectric Point: 10.4123

>T179987 WP_017900571.1 NZ_CP064044:4533991-4534272 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T179987 NZ_CP084924:c17675-17382 [Acinetobacter pittii]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAGACTCCCTGTTGCTATACGAGATCAATTTAA
GAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TTAAATTATTAAAAGCTGGTGTCAGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCTTGCTCATCACAGTCGGG
AAACGAGCTGATAGCATAGTTTATGACGAAGCTAAAAAGCGCATTAAAGACTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9117.61 Da
• Isoelectric Point: 5.1486

>AT179987 WP_048322784.1 NZ_CP064044:4533759-4534001 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT179987 NZ_CP084924:c17910-17665 [Acinetobacter pittii]
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCCTATTCCATCCTTAAAGAACAAGGTATTGCACC
TACAGATTTCTTTACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTACCTGTCAAAAAAGCTTTGCTTTCAGAAG
AAGACGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGACCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Structures

Toxin

• AlphaFold DB: A0A663BE04