Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1350168..1351756 Replicon chromosome
Accession NZ_CP064044
Organism Klebsiella quasipneumoniae strain BM404-3-1

Toxin (Protein)


Gene name hipA Uniprot ID A0A5Q9LEV0
Locus tag ISA72_RS06590 Protein ID WP_043519554.1
Coordinates 1350434..1351756 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag ISA72_RS06585 Protein ID WP_004205921.1
Coordinates 1350168..1350434 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA72_RS06560 1345301..1346224 + 924 WP_053810397.1 LysR family hpxDE operon transcriptional regulator HpxR -
ISA72_RS06565 1346205..1347359 - 1155 WP_053810396.1 FAD-dependent urate hydroxylase HpxO -
ISA72_RS06570 1347705..1349084 + 1380 WP_017900377.1 purine permease -
ISA72_RS06575 1349062..1349562 + 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
ISA72_RS06580 1349559..1349885 + 327 WP_064794852.1 hydroxyisourate hydrolase -
ISA72_RS06585 1350168..1350434 + 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
ISA72_RS06590 1350434..1351756 + 1323 WP_043519554.1 type II toxin-antitoxin system HipA family toxin Toxin
ISA72_RS06595 1351773..1353065 - 1293 WP_023318214.1 glycoside hydrolase family 10 protein -
ISA72_RS06600 1353207..1353413 - 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
ISA72_RS06605 1353416..1353949 - 534 WP_004205916.1 hypothetical protein -
ISA72_RS06610 1353978..1354322 - 345 WP_004205915.1 hypothetical protein -
ISA72_RS06615 1354309..1355424 - 1116 WP_004205914.1 serine hydrolase -
ISA72_RS06620 1355693..1356475 - 783 WP_049003659.1 type I methionyl aminopeptidase -
ISA72_RS06625 1356456..1356674 - 219 WP_002904808.1 ParD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48998.30 Da        Isoelectric Point: 8.2655

>T179977 WP_043519554.1 NZ_CP064044:1350434-1351756 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLLAG

Download         Length: 1323 bp

>T179977 NZ_CP084922:11889-12197 [Acinetobacter pittii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGACGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT179977 WP_004205921.1 NZ_CP064044:1350168-1350434 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp

>AT179977 NZ_CP084922:12238-12540 [Acinetobacter pittii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTGGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGATTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LEV0

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References