Detailed information of TA system TA179976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2785189..2787017
• Replicon: chromosome
• Accession: NZ_CP064041
• Organism: Vibrio parahaemolyticus strain XMO116

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: H9J98_RS13145
• Protein ID: WP_062851242.1
• Coordinates: 2785189..2786550 (+)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: H9J98_RS13150
• Protein ID: WP_029786578.1
• Coordinates: 2786535..2787017 (+)
• Length: 161 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9J98_RS13135 (H9J98_13015)	2782913..2783299	+	387	WP_062851243.1	hypothetical protein	-
H9J98_RS13140 (H9J98_13020)	2783916..2784698	+	783	WP_031428771.1	metallophosphoesterase	-
H9J98_RS13145 (H9J98_13025)	2785189..2786550	+	1362	WP_062851242.1	type II toxin-antitoxin system HipA family toxin	Toxin
H9J98_RS13150 (H9J98_13030)	2786535..2787017	+	483	WP_029786578.1	helix-turn-helix transcriptional regulator	Antitoxin
H9J98_RS13155 (H9J98_13035)	2787800..2788363	-	564	WP_015296308.1	porin family protein	-
H9J98_RS13160 (H9J98_13040)	2788763..2789653	+	891	WP_045607387.1	LysR family transcriptional regulator	-
H9J98_RS13165 (H9J98_13045)	2789789..2791321	+	1533	WP_005464264.1	bifunctional GNAT family N-acetyltransferase/carbon-nitrogen hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2757018..2789653	32635

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-385)

Antitoxin

• Cro/C1-type helix-turn-helix domain (88-139)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51397.15 Da
• Isoelectric Point: 4.8182

>T179976 WP_062851242.1 NZ_CP064041:2785189-2786550 [Vibrio parahaemolyticus]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCIDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Nucleotide

• Length: 1362 bp

>T179976 NZ_CP084922:10278-10571 [Acinetobacter pittii]
ATGACTTATAAGCTTTTACGTAATAAGGACTTCACAGCTGAATGGGAAAAGCTTCCTAGTGCTATAAGAGATCAATTTAA
GAAGAAACTCGCCAAGGTCATAGAGCAGCCACATATTCCCAAGAATATGCTTAGAGGTGATCTCACGGGATGTTATAAAA
TTAAATTACTAAAGACTGGAGTTCGACTGGTCTATCAAGTCAAAGATGATCAGGTAGTTATCTTGCTCATCACCGTTGGG
AAACGAGCTGACAGCATAGTTTATGACGAAGCAAAAAAACGCATTAAAGACTAA

Antitoxin

Protein

• Length: 161 a.a.
• Molecular weight: 17535.05 Da
• Isoelectric Point: 10.8446

>AT179976 WP_029786578.1 NZ_CP064041:2786535-2787017 [Vibrio parahaemolyticus]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Nucleotide

• Length: 483 bp

>AT179976 NZ_CP084922:10043-10288 [Acinetobacter pittii]
ATGGCTACTGTTAACTTCAGGGTTGATGAAGCCCTTAAAGAAAAATCTTATTCAGTTCTTAGAGAACAAGGTATTGCACC
TACTGAGTTTTTTACAAATGTCCTTGAATACATTGCAGCGACTGGGAAACTCCCTGTACAAAAAGCTTTACTCTCAGAAG
AGGATACCGAGCTATTAGCGATTGTTCGTAAACGTATGAATGATCCTAAAGAAATGTTCGAGGAAATTACTTTAGATGAC
TTATAA