Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 2178872..2179431 | Replicon | chromosome |
| Accession | NZ_CP064037 | ||
| Organism | Vibrio parahaemolyticus strain XMM117 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | H9J99_RS10125 | Protein ID | WP_053312146.1 |
| Coordinates | 2179153..2179431 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | H9J99_RS10120 | Protein ID | WP_053312147.1 |
| Coordinates | 2178872..2179156 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9J99_RS10090 (H9J99_10020) | 2174216..2174968 | - | 753 | WP_248339883.1 | IS21-like element helper ATPase IstB | - |
| H9J99_RS10095 (H9J99_10025) | 2174984..2176525 | - | 1542 | WP_248339881.1 | IS21 family transposase | - |
| H9J99_RS10100 (H9J99_10030) | 2176753..2177160 | - | 408 | WP_282575046.1 | NAD(P)H-dependent oxidoreductase | - |
| H9J99_RS10105 | 2177149..2177235 | - | 87 | Protein_1953 | DUF3265 domain-containing protein | - |
| H9J99_RS10110 (H9J99_10035) | 2177253..2177729 | - | 477 | WP_029836910.1 | GNAT family N-acetyltransferase | - |
| H9J99_RS10115 (H9J99_10040) | 2177849..2178670 | - | 822 | WP_020840798.1 | DUF2002 family protein | - |
| H9J99_RS10120 (H9J99_10045) | 2178872..2179156 | + | 285 | WP_053312147.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| H9J99_RS10125 (H9J99_10050) | 2179153..2179431 | + | 279 | WP_053312146.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| H9J99_RS10130 (H9J99_10055) | 2179569..2180015 | - | 447 | WP_031817701.1 | GNAT family N-acetyltransferase | - |
| H9J99_RS10135 (H9J99_10060) | 2180630..2180722 | - | 93 | WP_222133812.1 | DUF3265 domain-containing protein | - |
| H9J99_RS10140 (H9J99_10065) | 2180737..2181186 | - | 450 | WP_176296809.1 | hypothetical protein | - |
| H9J99_RS10145 (H9J99_10070) | 2181189..2181533 | - | 345 | WP_176296810.1 | hypothetical protein | - |
| H9J99_RS10150 (H9J99_10075) | 2181660..2182094 | - | 435 | WP_100088283.1 | GNAT family N-acetyltransferase | - |
| H9J99_RS10155 (H9J99_10080) | 2182255..2182809 | - | 555 | WP_053319305.1 | YkgJ family cysteine cluster protein | - |
| H9J99_RS10160 (H9J99_10085) | 2182837..2182926 | - | 90 | WP_071881309.1 | DUF3265 domain-containing protein | - |
| H9J99_RS10165 (H9J99_10090) | 2183449..2183541 | - | 93 | WP_079751132.1 | DUF3265 domain-containing protein | - |
| H9J99_RS10170 (H9J99_10095) | 2183569..2184252 | - | 684 | WP_069529237.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2135070..2247242 | 112172 | |
| - | inside | Integron | - | - | 2176753..2212601 | 35848 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10880.55 Da Isoelectric Point: 4.3324
>T179974 WP_053312146.1 NZ_CP064037:2179153-2179431 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAADKTDEIIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSVIRIM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPDAADKTDEIIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSVIRIM
RVLHQKQKFPTD
Download Length: 279 bp
>T179974 NZ_CP084921:1791798-1791980 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10913.19 Da Isoelectric Point: 8.0515
>AT179974 WP_053312147.1 NZ_CP064037:2178872-2179156 [Vibrio parahaemolyticus]
MDTRIQFRVDDEVKRLAQQMAESQGRTLSDACRELTEQMAEQQRKALSHDNWLTEQVNLAFEKFDSGKASFVDHDSAKAR
MAERKAKIRNRGQQ
MDTRIQFRVDDEVKRLAQQMAESQGRTLSDACRELTEQMAEQQRKALSHDNWLTEQVNLAFEKFDSGKASFVDHDSAKAR
MAERKAKIRNRGQQ
Download Length: 285 bp
>AT179974 NZ_CP084921:1792073-1792477 [Acinetobacter pittii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|