Detailed information of TA system TA179970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1929639..1930198
• Replicon: chromosome
• Accession: NZ_CP064035
• Organism: Vibrio parahaemolyticus strain DLM1799

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H9K44_RS08925
• Protein ID: WP_169608457.1
• Coordinates: 1929920..1930198 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3Q0L0M2
• Locus tag: H9K44_RS08920
• Protein ID: WP_011082348.1
• Coordinates: 1929639..1929923 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9K44_RS08895 (H9K44_08900)	1924916..1925374	-	459	WP_005434032.1	hypothetical protein	-
H9K44_RS08900 (H9K44_08905)	1925403..1925495	-	93	WP_248385889.1	DUF3265 domain-containing protein	-
H9K44_RS08905 (H9K44_08910)	1925520..1926392	-	873	WP_169608453.1	DUF6236 family protein	-
H9K44_RS08910 (H9K44_08915)	1926996..1927118	-	123	WP_139150442.1	DUF3265 domain-containing protein	-
H9K44_RS08915 (H9K44_08920)	1928739..1929425	-	687	WP_169608455.1	GNAT family N-acetyltransferase	-
H9K44_RS08920 (H9K44_08925)	1929639..1929923	+	285	WP_011082348.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H9K44_RS08925 (H9K44_08930)	1929920..1930198	+	279	WP_169608457.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H9K44_RS08930 (H9K44_08935)	1930305..1930844	-	540	WP_151514909.1	hypothetical protein	-
H9K44_RS08935 (H9K44_08940)	1930979..1931791	-	813	WP_062852340.1	hypothetical protein	-
H9K44_RS08940	1931837..1931887	-	51	WP_223304363.1	hypothetical protein	-
H9K44_RS08945	1932415..1932465	-	51	WP_238822025.1	hypothetical protein	-
H9K44_RS08950 (H9K44_08950)	1932983..1933270	-	288	WP_045390295.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H9K44_RS08955 (H9K44_08955)	1933267..1933548	-	282	WP_011080399.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
H9K44_RS08960 (H9K44_08960)	1933759..1934235	-	477	WP_149150408.1	GNAT family N-acetyltransferase	-
H9K44_RS08965 (H9K44_08965)	1934356..1935156	-	801	WP_169608461.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1897527..1983557	86030
	-	inside	Integron	-	-	1910304..1967694	57390

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-45)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10926.62 Da
• Isoelectric Point: 4.3430

>T179970 WP_169608457.1 NZ_CP064035:1929920-1930198 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDYLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMVVSYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T179970 NZ_CP084916:1839963-1840235 [Carnobacterium viridans]
ATCAATTCAGGTTATCAAGTAGCGTTTGAAAAAGGAGCACAAAAGGCTTTAAAAAAGATGGATAAGCACCAGTCTCTTTT
AATTATGGGATGGATTCAAAAGAATCTAGTGAATTGTACAGATCCTAGGAAACAAGGAAAAGGACTGACCGCCAATCGTT
CAGGAGAATGGCGTTATAGAATTGGAGATTATCGCTTAATTGCTGATATCAGTGACGAGAGAGTCCCTATTTTAATGTTA
GAGATTGGGCATAGGAAAGATAGTTATAAGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11083.43 Da
• Isoelectric Point: 9.2167

>AT179970 WP_011082348.1 NZ_CP064035:1929639-1929923 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT179970 NZ_CP084916:1839741-1839962 [Carnobacterium viridans]
ATGACTGTAGTATCCCTAAGAATTGATGACCACGAAGATAAATTGATTAAAGAATATGCTAAAGCTAATAATATCTCGGT
TTCTACTTTATTTAGAAATGCTGTTTTAGAAAAAATTGAAGATGAAATTGATTTGGGTTTATATAACCAAGCTATGTCTG
AACACAAAGAAAATCCGCGAAGTATTTCTTTTGAAGATATGCTAAAGGAGTTAGCGGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A3Q0L0M2