Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1917040..1917587 | Replicon | chromosome |
| Accession | NZ_CP064035 | ||
| Organism | Vibrio parahaemolyticus strain DLM1799 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A347UR19 |
| Locus tag | H9K44_RS08815 | Protein ID | WP_025548916.1 |
| Coordinates | 1917040..1917342 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | H9K44_RS08820 | Protein ID | WP_169608435.1 |
| Coordinates | 1917330..1917587 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9K44_RS08780 (H9K44_08785) | 1912551..1913075 | - | 525 | WP_029785320.1 | DUF4823 domain-containing protein | - |
| H9K44_RS08785 (H9K44_08790) | 1913258..1913548 | - | 291 | WP_212568496.1 | hypothetical protein | - |
| H9K44_RS08790 (H9K44_08795) | 1913807..1914367 | - | 561 | WP_169608402.1 | hypothetical protein | - |
| H9K44_RS08795 (H9K44_08800) | 1914396..1914527 | - | 132 | WP_141180092.1 | DUF3265 domain-containing protein | - |
| H9K44_RS08800 (H9K44_08805) | 1915124..1915885 | - | 762 | WP_141180102.1 | hypothetical protein | - |
| H9K44_RS08805 (H9K44_08810) | 1916038..1916862 | - | 825 | WP_228513948.1 | hypothetical protein | - |
| H9K44_RS08810 (H9K44_08815) | 1916912..1917001 | - | 90 | WP_072016691.1 | DUF3265 domain-containing protein | - |
| H9K44_RS08815 (H9K44_08820) | 1917040..1917342 | - | 303 | WP_025548916.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H9K44_RS08820 (H9K44_08825) | 1917330..1917587 | - | 258 | WP_169608435.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| H9K44_RS08825 (H9K44_08830) | 1917787..1918071 | - | 285 | WP_169608437.1 | MazG nucleotide pyrophosphohydrolase domain-containing protein | - |
| H9K44_RS08830 (H9K44_08835) | 1918116..1918208 | - | 93 | WP_078555087.1 | DUF3265 domain-containing protein | - |
| H9K44_RS08835 (H9K44_08840) | 1918223..1918705 | - | 483 | WP_089202935.1 | hypothetical protein | - |
| H9K44_RS08840 | 1919323..1919493 | - | 171 | WP_248385771.1 | hypothetical protein | - |
| H9K44_RS08845 (H9K44_08850) | 1919878..1920291 | - | 414 | WP_169608439.1 | hypothetical protein | - |
| H9K44_RS08850 (H9K44_08855) | 1920811..1920903 | - | 93 | WP_072612521.1 | DUF3265 domain-containing protein | - |
| H9K44_RS08855 (H9K44_08860) | 1920918..1921412 | - | 495 | WP_169608441.1 | hypothetical protein | - |
| H9K44_RS08860 (H9K44_08865) | 1921536..1921808 | - | 273 | WP_169608443.1 | hypothetical protein | - |
| H9K44_RS08865 (H9K44_08870) | 1921837..1921929 | - | 93 | WP_248385773.1 | DUF3265 domain-containing protein | - |
| H9K44_RS08870 (H9K44_08875) | 1921954..1922343 | - | 390 | WP_005500319.1 | hypothetical protein | - |
| H9K44_RS08875 (H9K44_08880) | 1922380..1922457 | - | 78 | WP_071652531.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1897527..1983557 | 86030 | |
| - | inside | Integron | - | - | 1910304..1967694 | 57390 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11669.57 Da Isoelectric Point: 5.1765
>T179969 WP_025548916.1 NZ_CP064035:c1917342-1917040 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T179969 NZ_CP084916:546957-547301 [Carnobacterium viridans]
ATGGATAGCGTCTTTGATTTACTTGAACTAAATAACATTGAGTTAGTTTTGATAAGTATTGAGAGCAATGGATATTATGA
TCCTGCTCTAAATATCATTTTCATTAATCAACTATTAGATGAGGAAAAACAAAAAGAGGTCATCCTTCATGAATTAGGAC
ATGTTCTTAATCATAAGGATTTAGCTTCTTTATATAGCAATAAATCATACCGTTCTAAAATGGAAAACGAAGCAACTAAG
TTTATGATTAAATACTTGATAAATGAATGTGAAGGACAATTCAATTATTCGAGTGTTTTAGAAAAGTATAATTTAGGTAT
AGGTTGGGAAGGCAAAATTAAATAA
ATGGATAGCGTCTTTGATTTACTTGAACTAAATAACATTGAGTTAGTTTTGATAAGTATTGAGAGCAATGGATATTATGA
TCCTGCTCTAAATATCATTTTCATTAATCAACTATTAGATGAGGAAAAACAAAAAGAGGTCATCCTTCATGAATTAGGAC
ATGTTCTTAATCATAAGGATTTAGCTTCTTTATATAGCAATAAATCATACCGTTCTAAAATGGAAAACGAAGCAACTAAG
TTTATGATTAAATACTTGATAAATGAATGTGAAGGACAATTCAATTATTCGAGTGTTTTAGAAAAGTATAATTTAGGTAT
AGGTTGGGAAGGCAAAATTAAATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9632.18 Da Isoelectric Point: 8.5338
>AT179969 WP_169608435.1 NZ_CP064035:c1917587-1917330 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVNHDKAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVNHDKAKDKM
SKWLK
Download Length: 258 bp
>AT179969 NZ_CP084916:546626-546946 [Carnobacterium viridans]
ATGGGAATAGTAGACAGAATAAAAATATTGTGCGATAGTCATAAAACGACTTTTGCGGAGGTTGAAAGACACGTAGGTTT
ATCTAATGGACAAATTAGAAGATGGGATACTGCTTCTCCAAAATTAGAGAATATAGAAAAAGTGGCTGATTACTTTGATG
TTTCAGTTGACTACCTACGAGGAAAAGATACTAAAGTTACGTTGCCTACTGATTTAGATAAAGTTTTAGACGGCATGATG
AGTTTTGACGGAAAACCTATGACTGAAAATGATAGAGAGTCAATTCGTGCTTATCTTGAAGGAAGATTTAGCGATAAGTG
A
ATGGGAATAGTAGACAGAATAAAAATATTGTGCGATAGTCATAAAACGACTTTTGCGGAGGTTGAAAGACACGTAGGTTT
ATCTAATGGACAAATTAGAAGATGGGATACTGCTTCTCCAAAATTAGAGAATATAGAAAAAGTGGCTGATTACTTTGATG
TTTCAGTTGACTACCTACGAGGAAAAGATACTAAAGTTACGTTGCCTACTGATTTAGATAAAGTTTTAGACGGCATGATG
AGTTTTGACGGAAAACCTATGACTGAAAATGATAGAGAGTCAATTCGTGCTTATCTTGAAGGAAGATTTAGCGATAAGTG
A
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|