Detailed information of TA system TA179967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1383763..1384310
• Replicon: chromosome
• Accession: NZ_CP064033
• Organism: Vibrio parahaemolyticus strain DLM1805

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H9K48_RS06810
• Protein ID: WP_025793438.1
• Coordinates: 1384008..1384310 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3A269
• Locus tag: H9K48_RS06805
• Protein ID: WP_005448240.1
• Coordinates: 1383763..1384020 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9K48_RS06750 (H9K48_06725)	1378805..1379482	+	678	WP_025793485.1	hypothetical protein	-
H9K48_RS06755 (H9K48_06730)	1379506..1379598	+	93	WP_072612521.1	DUF3265 domain-containing protein	-
H9K48_RS06760 (H9K48_06735)	1380068..1380160	+	93	WP_005494820.1	DUF3265 domain-containing protein	-
H9K48_RS06765 (H9K48_06740)	1380188..1380568	+	381	WP_104411071.1	hypothetical protein	-
H9K48_RS06770 (H9K48_06745)	1380685..1381032	+	348	WP_025793492.1	zinc ribbon domain-containing protein	-
H9K48_RS06775 (H9K48_06750)	1381058..1381150	+	93	WP_072606053.1	DUF3265 domain-containing protein	-
H9K48_RS06780 (H9K48_06755)	1381670..1381759	+	90	WP_074190212.1	DUF3265 domain-containing protein	-
H9K48_RS06785 (H9K48_06760)	1381808..1382413	+	606	WP_140142847.1	hypothetical protein	-
H9K48_RS06790 (H9K48_06765)	1382439..1382531	+	93	WP_080259420.1	DUF3265 domain-containing protein	-
H9K48_RS06795 (H9K48_06770)	1382974..1383102	+	129	WP_080277532.1	DUF3265 domain-containing protein	-
H9K48_RS06800 (H9K48_06775)	1383130..1383603	+	474	WP_025534629.1	hypothetical protein	-
H9K48_RS06805 (H9K48_06780)	1383763..1384020	+	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H9K48_RS06810 (H9K48_06785)	1384008..1384310	+	303	WP_025793438.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H9K48_RS06815 (H9K48_06790)	1384477..1385022	+	546	WP_025793483.1	hypothetical protein	-
H9K48_RS06820 (H9K48_06795)	1385165..1385716	+	552	WP_224067025.1	hypothetical protein	-
H9K48_RS06825 (H9K48_06800)	1385731..1385823	+	93	WP_005494856.1	DUF3265 domain-containing protein	-
H9K48_RS06830 (H9K48_06805)	1385868..1386152	+	285	WP_017448465.1	MazG nucleotide pyrophosphohydrolase domain-containing protein	-
H9K48_RS06835 (H9K48_06810)	1386160..1386270	+	111	WP_082798391.1	DUF3265 domain-containing protein	-
H9K48_RS06840 (H9K48_06815)	1386302..1386607	+	306	WP_021453216.1	hypothetical protein	-
H9K48_RS06845 (H9K48_06820)	1386856..1387098	+	243	WP_080765108.1	zinc ribbon domain-containing protein	-
H9K48_RS06850 (H9K48_06825)	1387124..1387216	+	93	WP_078235736.1	DUF3265 domain-containing protein	-
H9K48_RS06855	1387675..1387764	+	90	WP_072832911.1	DUF3265 domain-containing protein	-
H9K48_RS06860 (H9K48_06835)	1387857..1388234	+	378	WP_086583718.1	hypothetical protein	-
H9K48_RS06865 (H9K48_06840)	1388376..1389101	+	726	WP_025793457.1	class I SAM-dependent methyltransferase	-
H9K48_RS06870 (H9K48_06845)	1389123..1389215	+	93	WP_079882702.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vpadF	1355097..1423833	68736
	-	inside	Integron	-	-	1308270..1399759	91489

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11536.51 Da
• Isoelectric Point: 5.8623

>T179967 WP_025793438.1 NZ_CP064033:1384008-1384310 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQAIFSKVERLVAFPESGRIPPELAHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T179967 NZ_CP084914:c3350240-3349917 [Leptospira borgpetersenii]
ATGGTGATTTCTCAATACGAAGTATATTTGATAAATTTGGATCCAACGGTCGGACATGAGATTAAAAAATCAAGACCTTG
CGTAATAATCTCACCTAATGAAATGAATAAAACTATCGGAACAATTATTATTACACCAATGACTACCAAATCTCGGTCAT
ATCCAACAAGAGTCGAATTAACATTTCAAGGAAAGAAAGGCTGGATTGTGTTAGATCAAATTCGAACTGTAGATAAAATA
CGTCTGATAAAAAAGTTAGGAAAAATAGATCCCAAAACAGTTAATAAAATGAAACTGATTATAAAGGAAATGTTGGTTGA
TTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9606.10 Da
• Isoelectric Point: 6.7269

>AT179967 WP_005448240.1 NZ_CP064033:1383763-1384020 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT179967 NZ_CP084914:c3350482-3350234 [Leptospira borgpetersenii]
ATGAAGGCTTTAGTTGTAAAAATAGGTAATTCAAAAGGAATTCGGATTCCCAAAGCGGTTTTAGAAGAATGCCATATTGA
AGAAGAAGTAGATTTACTAATCGATAATAATAAATTAATTATTGTGCCTCTAAAATCGAAACCAAGAGAAGGGTGGGAAA
AACAATTTAAATCAATGTCATCTAATAAAGATGATAAATTGCTTGTTCCTGATTCAATAGATTTATCGGATAAGGATTGG
GAATGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A432DGX8