Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2929422..2930016 Replicon chromosome
Accession NZ_CP064030
Organism Dyella caseinilytica strain DHOB09

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag ISN74_RS12585 Protein ID WP_188801113.1
Coordinates 2929422..2929709 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag ISN74_RS12590 Protein ID WP_188801115.1
Coordinates 2929717..2930016 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISN74_RS12550 2925721..2926053 - 333 WP_188801101.1 lipid-A-disaccharide synthase N-terminal domain-containing protein -
ISN74_RS12560 2926344..2926625 - 282 WP_203546604.1 hypothetical protein -
ISN74_RS12565 2926737..2927231 - 495 WP_188801105.1 hypothetical protein -
ISN74_RS12570 2927215..2927553 - 339 WP_188801107.1 hypothetical protein -
ISN74_RS12575 2927567..2927953 - 387 WP_188801109.1 hypothetical protein -
ISN74_RS12580 2927956..2928969 - 1014 WP_188801111.1 hypothetical protein -
ISN74_RS12585 2929422..2929709 + 288 WP_188801113.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISN74_RS12590 2929717..2930016 + 300 WP_188801115.1 putative addiction module antidote protein Antitoxin
ISN74_RS12595 2930083..2930334 + 252 WP_188801117.1 hypothetical protein -
ISN74_RS12600 2930677..2932830 - 2154 WP_188801118.1 toprim domain-containing protein -
ISN74_RS12605 2932827..2933057 - 231 WP_188801121.1 helix-turn-helix domain-containing protein -
ISN74_RS12610 2933344..2934483 - 1140 WP_188801122.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-92)

Antitoxin

Uncharacterized protein HI1420

(9-95)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10282.99 Da        Isoelectric Point: 10.3420

>T179965 WP_188801113.1 NZ_CP064030:2929422-2929709 [Dyella caseinilytica]
MDIKTTATFDTWLAGLRDRKAAAIITARIVRVAGGLLGDVKSVGGPVNELRIDYGPGYRVYFIKQGKTVIVLLCGGDKST
QQHDIKQAQKLALNP

Download         Length: 288 bp

>T179965 NZ_CP084910:c2225833-2225555 [Asticcacaulis sp. AND118]
ATGATGATCCAATGGTCCGCGCGGGCGCTGAACGACCGTATTCAGACCTTTCAATTCATCGCGCAGGACAGTGTCGCGGC
GGCGGTCAGGGTGGATGAAGCTGTGGAAGCCGCCGCGGAACACTTGATCGACTTTCCGGACAGCGGTCGACCCGGCCGGG
CGAGGCGCACGCGCGAATGGGTGCTGAATGGCCTGCCGTACCTGCTTATCTACACGGTCGAAGGCGATGCGATAGTGATC
TGGCGCGTTCTGCACACCTCACGGCTGTGGCCCGAATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10705.17 Da        Isoelectric Point: 5.1486

>AT179965 WP_188801115.1 NZ_CP064030:2929717-2930016 [Dyella caseinilytica]
MKAEQIRNLKTFDPAEYLNTDEAIAAFLEDAIESGDNRVFQEALSIAARARGMAEIAKAAGLGRESLYKALRPDANPRFD
TVQRVLAALGVRLSVSAAP

Download         Length: 300 bp

>AT179965 NZ_CP084910:c2226120-2225830 [Asticcacaulis sp. AND118]
ATGGCGGCGAGCGAAGTGGTACAAGCGCGGATCGATCGTGCGATCAAGGAACGGGCGGGCGCCGTCCTCAGCCAGATGGG
GCTGACGGTTTCCGACGCCGTGCGTATCCTGCTGACGCGTATTGCCAATGAAGGAACCCTGCCGGCCGGGTTGACCGTCG
ATCCGGAAACCTATGACGCCTGGTTACGGGCTAAGGTGCAGGAGGCCATGAACGATCCGCGGCCTCTGGTCTCCCATGAC
GAGGCCAAGGCGCGCATGGCCGCGCTCAGGGCGGATGCTCTGCGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References