Detailed information of TA system TA179964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 36356..36954
• Replicon: chromosome
• Accession: NZ_CP064030
• Organism: Dyella caseinilytica strain DHOB09

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ISN74_RS00160
• Protein ID: WP_188799417.1
• Coordinates: 36356..36649 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ISN74_RS00165
• Protein ID: WP_188796203.1
• Coordinates: 36652..36954 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISN74_RS00135	32181..32546	-	366	WP_188796195.1	cupin domain-containing protein	-
ISN74_RS00140	32589..33488	-	900	WP_188796197.1	LysR family transcriptional regulator	-
ISN74_RS00145	33602..34330	+	729	WP_188799416.1	SDR family oxidoreductase	-
ISN74_RS00150	34400..34945	-	546	WP_188796199.1	hypothetical protein	-
ISN74_RS00155	35166..36296	+	1131	WP_188796201.1	poly(3-hydroxybutyrate) depolymerase	-
ISN74_RS00160	36356..36649	+	294	WP_188799417.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ISN74_RS00165	36652..36954	+	303	WP_188796203.1	putative addiction module antidote protein	Antitoxin
ISN74_RS00170	37416..41330	+	3915	WP_203546671.1	patatin-like phospholipase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (2-95)

Antitoxin

• Uncharacterized protein HI1420 (10-94)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11234.92 Da
• Isoelectric Point: 9.9055

>T179964 WP_188799417.1 NZ_CP064030:36356-36649 [Dyella caseinilytica]
MEIVKSRMFDRWLRGLNDRQAKARIQMRIDRLNLGNPGQHRNLTGGIREMKIDYGPGYRVYYTIRGAVLIILLCGGDKTT
QQQDIDNAIRLADAWED

Nucleotide

• Length: 294 bp

>T179964 NZ_CP084910:778806-779093 [Asticcacaulis sp. AND118]
ATGGCTGAGACCTATCGCCTTCGACCGGCGGCGCGTGCCGATCTCGCCGATATCTGGCGATATAGCCGCACGCAATGGTC
GGTCGATCAGGCAGATCGCTATACGCGGTTGTTGATGACGGCGTTTGACGATCTGGCATCGGGCCGACGAAATGGCAAAC
CCGTCGTAGTGAGGGTGGGCTACCTGAAATATGCCTGCGGCTCACATATCATCTATTATCGGTTGGACAATGGACTCGAA
ATCGTTCGCGTTCTGCATCAGCGCATGGATGTCGAGATCAATCTTTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10778.22 Da
• Isoelectric Point: 5.0914

>AT179964 WP_188796203.1 NZ_CP064030:36652-36954 [Dyella caseinilytica]
MAAKKKEVFSRYDTADYLNSEEDIAAYLEACSEENDPALMAAALGAVARARNMSQLARDTGLTREGLYKALSVDGNPSLA
TAMRVANALGYQLRLVPLAH

Nucleotide

• Length: 303 bp

>AT179964 NZ_CP084910:778571-778813 [Asticcacaulis sp. AND118]
ATGACGCGCACGACTTCCATGTCTCTGGGGGAACATTTCACCAGATTTATCGCCACGCAGGTCGAAGAGGGCCGCTATGG
CTCGGCGTCCGATGTGGTGCGCGCCGGATTGCGGCTGCTCGAAGAACATGAGGCCAAGATCAAGGCGTTGCAGCAGGCGC
TGATCGAAGGCGAACAGTCCGGCGTTGCCGAAGCCTTTGACGGTGAAGCCTTTCTGAAAGAGATGCGCGCCGATCATGGC
TGA