Detailed information of TA system TA179947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 2309248..2309753
• Replicon: chromosome
• Accession: NZ_CP064000
• Organism: Xanthomonas translucens pv. undulosa strain XtKm12

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ISN35_RS10095
• Protein ID: WP_058358982.1
• Coordinates: 2309248..2309505 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1C3TRJ9
• Locus tag: ISN35_RS10100
• Protein ID: WP_003468816.1
• Coordinates: 2309502..2309753 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISN35_RS10065	2305062..2305730	+	669	WP_058196365.1	dTMP kinase	-
ISN35_RS10070	2305727..2306704	+	978	WP_058196366.1	DNA polymerase III subunit delta'	-
ISN35_RS10075	2306701..2307054	+	354	WP_039007341.1	PilZ domain-containing protein	-
ISN35_RS10085	2307401..2307961	+	561	WP_141696960.1	hypothetical protein	-
ISN35_RS10090	2308245..2308889	+	645	WP_081318762.1	DUF4145 domain-containing protein	-
ISN35_RS10095	2309248..2309505	-	258	WP_058358982.1	Txe/YoeB family addiction module toxin	Toxin
ISN35_RS10100	2309502..2309753	-	252	WP_003468816.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
ISN35_RS10105	2309910..2310674	+	765	WP_068873280.1	endonuclease	-
ISN35_RS10110	2310671..2311393	-	723	WP_058359018.1	ArsR family transcriptional regulator	-
ISN35_RS10115	2311517..2311966	+	450	WP_003468823.1	nuclear transport factor 2 family protein	-
ISN35_RS10120	2312135..2312824	+	690	WP_196479346.1	hypothetical protein	-
ISN35_RS10125	2312992..2313267	-	276	WP_003468826.1	hypothetical protein	-
ISN35_RS10130	2313602..2313892	+	291	WP_003468827.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10181.66 Da
• Isoelectric Point: 9.3936

>T179947 WP_058358982.1 NZ_CP064000:c2309505-2309248 [Xanthomonas translucens pv. undulosa]
VTLQFSDNAWEDDLYWQQTDKKMLKRVNDLIKAIQRDPFQGVGKPEPLRHALAGYWSRRINEEHRIVYRVEAGILLIAQV
RYHYL

Nucleotide

• Length: 258 bp

>T179947 NZ_CP084900:c1820708-1820331 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACAGCTCGC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9281.56 Da
• Isoelectric Point: 5.1186

>AT179947 WP_003468816.1 NZ_CP064000:c2309753-2309502 [Xanthomonas translucens pv. undulosa]
MDTITYSAARAALADTMERVVNNHEPVIITRSREQSVVMLSLEDYKAMEETAYLLRSPKSAQRLLESIAQLEAGRGKARD
LAE

Nucleotide

• Length: 252 bp

>AT179947 NZ_CP084900:c1821166-1820798 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1C3TRJ9