Detailed information of TA system TA179944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 3635828..3636240
• Replicon: chromosome
• Accession: NZ_CP063997
• Organism: Xanthomonas translucens pv. undulosa strain XtKm15

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ISN36_RS15605
• Protein ID: WP_206711825.1
• Coordinates: 3636046..3636240 (-)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ISN36_RS15600
• Protein ID: WP_206711826.1
• Coordinates: 3635828..3636040 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISN36_RS15580	3631101..3632777	+	1677	WP_068873386.1	hypothetical protein	-
ISN36_RS15585	3632849..3634438	+	1590	WP_206712220.1	DUF2357 domain-containing protein	-
ISN36_RS15590	3634438..3634917	+	480	WP_081324064.1	DNA mismatch endonuclease Vsr	-
ISN36_RS15595	3634962..3635597	-	636	WP_081324067.1	NYN domain-containing protein	-
ISN36_RS15600	3635828..3636040	-	213	WP_206711826.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ISN36_RS15605	3636046..3636240	-	195	WP_206711825.1	type II toxin-antitoxin system HicA family toxin	Toxin
ISN36_RS15610	3636353..3639043	-	2691	WP_206711824.1	pyruvate dehydrogenase (acetyl-transferring), homodimeric type	-
ISN36_RS15615	3639279..3641219	+	1941	WP_108085207.1	SpoIIE family protein phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3625907..3639043	13136

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-62)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7021.10 Da
• Isoelectric Point: 11.0837

>T179944 WP_206711825.1 NZ_CP063997:c3636240-3636046 [Xanthomonas translucens pv. undulosa]
MPPKIRDVLQQLKDAGWQQVGQTGSHRQFKHPVYPGRVTVAGKPSDDVAPGTMNSILKQAGLKR

Nucleotide

• Length: 195 bp

>T179944 NZ_CP084900:1031394-1031729 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGATTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7337.28 Da
• Isoelectric Point: 3.9202

>AT179944 WP_206711826.1 NZ_CP063997:c3636040-3635828 [Xanthomonas translucens pv. undulosa]
MRYAVVIEQAGNNYSAYVPDLAGCVATGATTAEVAGLIREAIELHLAGMREDGEVIPLPSSQVEYVDVAA

Nucleotide

• Length: 213 bp

>AT179944 NZ_CP084900:1031146-1031394 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA