Detailed information of TA system TA179939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 2883186..2883598
• Replicon: chromosome
• Accession: NZ_CP063993
• Organism: Xanthomonas translucens pv. undulosa strain XtLr8

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ISN38_RS12170
• Protein ID: WP_206711825.1
• Coordinates: 2883186..2883380 (+)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ISN38_RS12175
• Protein ID: WP_206711826.1
• Coordinates: 2883386..2883598 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISN38_RS12160	2878207..2880147	-	1941	WP_108085207.1	SpoIIE family protein phosphatase	-
ISN38_RS12165	2880383..2883073	+	2691	WP_206711824.1	pyruvate dehydrogenase (acetyl-transferring), homodimeric type	-
ISN38_RS12170	2883186..2883380	+	195	WP_206711825.1	type II toxin-antitoxin system HicA family toxin	Toxin
ISN38_RS12175	2883386..2883598	+	213	WP_206711826.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ISN38_RS12180	2883829..2884464	+	636	WP_081324067.1	NYN domain-containing protein	-
ISN38_RS12185	2884509..2884988	-	480	WP_081324064.1	DNA mismatch endonuclease Vsr	-
ISN38_RS12190	2884988..2886577	-	1590	WP_206712220.1	DUF2357 domain-containing protein	-
ISN38_RS12195	2886649..2888325	-	1677	WP_068873386.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-62)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7021.10 Da
• Isoelectric Point: 11.0837

>T179939 WP_206711825.1 NZ_CP063993:2883186-2883380 [Xanthomonas translucens pv. undulosa]
MPPKIRDVLQQLKDAGWQQVGQTGSHRQFKHPVYPGRVTVAGKPSDDVAPGTMNSILKQAGLKR

Nucleotide

• Length: 195 bp

>T179939 NZ_CP084900:186661-186768 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7337.28 Da
• Isoelectric Point: 3.9202

>AT179939 WP_206711826.1 NZ_CP063993:2883386-2883598 [Xanthomonas translucens pv. undulosa]
MRYAVVIEQAGNNYSAYVPDLAGCVATGATTAEVAGLIREAIELHLAGMREDGEVIPLPSSQVEYVDVAA

Nucleotide

• Length: 213 bp

>AT179939 NZ_CP084900:c186612-186549 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT