Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4627734..4628377 Replicon chromosome
Accession NZ_CP063992
Organism Klebsiella pneumoniae strain M164-1

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag HXS86_RS22555 Protein ID WP_032433387.1
Coordinates 4627734..4628150 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag HXS86_RS22560 Protein ID WP_001261276.1
Coordinates 4628147..4628377 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS86_RS22525 (4622903) 4622903..4623106 - 204 WP_032433376.1 HHA domain-containing protein -
HXS86_RS22530 (4623166) 4623166..4623657 - 492 WP_032433378.1 hypothetical protein -
HXS86_RS22535 (4623688) 4623688..4624206 - 519 WP_045326794.1 hypothetical protein -
HXS86_RS22540 (4624265) 4624265..4624513 - 249 WP_032433382.1 hypothetical protein -
HXS86_RS22545 (4624832) 4624832..4626403 + 1572 WP_032433383.1 AAA family ATPase -
HXS86_RS22550 (4626598) 4626598..4627578 - 981 WP_032433385.1 hypothetical protein -
HXS86_RS22555 (4627734) 4627734..4628150 - 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
HXS86_RS22560 (4628147) 4628147..4628377 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HXS86_RS22565 (4628682) 4628682..4629497 + 816 WP_032433388.1 hypothetical protein -
HXS86_RS22570 (4630025) 4630025..4632265 - 2241 WP_045326788.1 P-loop NTPase fold protein -
HXS86_RS22575 (4632268) 4632268..4633355 - 1088 Protein_4416 transcriptional repressor PifC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4600007..4643741 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T179935 WP_032433387.1 NZ_CP063992:c4628150-4627734 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T179935 NZ_CP084899:4362438-4362611 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT179935 WP_001261276.1 NZ_CP063992:c4628377-4628147 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT179935 NZ_CP084899:4362114-4362410 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References