Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1406563..1407079 Replicon chromosome
Accession NZ_CP063992
Organism Klebsiella pneumoniae strain M164-1

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag HXS86_RS06925 Protein ID WP_009486548.1
Coordinates 1406795..1407079 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HXS86_RS06920 Protein ID WP_002886901.1
Coordinates 1406563..1406805 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS86_RS06905 (1402591) 1402591..1403331 + 741 WP_009486551.1 KDGP aldolase family protein -
HXS86_RS06910 (1403398) 1403398..1404552 + 1155 WP_002886900.1 lactonase family protein -
HXS86_RS06915 (1404575) 1404575..1406485 + 1911 WP_009486549.1 PRD domain-containing protein -
HXS86_RS06920 (1406563) 1406563..1406805 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HXS86_RS06925 (1406795) 1406795..1407079 + 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HXS86_RS06930 (1407083) 1407083..1407547 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HXS86_RS06935 (1407855) 1407855..1409993 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HXS86_RS06940 (1410350) 1410350..1411093 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HXS86_RS06945 (1411096) 1411096..1411269 - 174 WP_032433782.1 hypothetical protein -
HXS86_RS06950 (1411399) 1411399..1411662 + 264 WP_014908078.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T179922 WP_009486548.1 NZ_CP063992:1406795-1407079 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T179922 NZ_CP084899:c1648978-1648691 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT179922 WP_002886901.1 NZ_CP063992:1406563-1406805 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT179922 NZ_CP084899:c1649217-1648978 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References