Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 734639..735197 Replicon chromosome
Accession NZ_CP063989
Organism Actinomyces sp. ZJ750

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ID810_RS03015 Protein ID WP_166855219.1
Coordinates 734639..734959 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ID810_RS03020 Protein ID WP_166855218.1
Coordinates 734964..735197 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ID810_RS02985 729699..729998 + 300 WP_196781517.1 DUF86 domain-containing protein -
ID810_RS02990 730076..730822 - 747 WP_166855223.1 ABC transporter permease -
ID810_RS02995 730824..731820 - 997 Protein_581 ABC transporter ATP-binding protein -
ID810_RS03000 731817..732101 - 285 WP_166855222.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
ID810_RS03005 732563..733315 + 753 WP_166855221.1 NAD(P)H-binding protein -
ID810_RS03010 733607..734557 - 951 WP_166855220.1 fructosamine kinase family protein -
ID810_RS03015 734639..734959 - 321 WP_166855219.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ID810_RS03020 734964..735197 - 234 WP_166855218.1 ribbon-helix-helix domain-containing protein Antitoxin
ID810_RS03025 737070..737984 - 915 WP_166855217.1 alpha/beta hydrolase -
ID810_RS03030 737981..738781 - 801 WP_166855216.1 alpha/beta hydrolase -
ID810_RS03035 738778..740133 - 1356 WP_166855215.1 sugar porter family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 729349..737984 8635


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-96)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11479.40 Da        Isoelectric Point: 7.8692

>T179917 WP_166855219.1 NZ_CP063989:c734959-734639 [Actinomyces sp. ZJ750]
MREIVLAHLDKTRPVLVLTRDRARDAMTKVSVAPITSTVKGLSSELPLGARNGLDHECVASMDNITTLPSRCLGRTIGFL
TVDQEPALARALILAFDLDIPLTGRT

Download         Length: 321 bp

>T179917 NZ_CP084899:c1270551-1270444 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8547.48 Da        Isoelectric Point: 4.1319

>AT179917 WP_166855218.1 NZ_CP063989:c735197-734964 [Actinomyces sp. ZJ750]
MSTQIAVRLPEDLVAFLDEVVAQGEAPSRAAAVARALERERRERAAAEDARILAELGPQDDLDDLVEWNARATRFED

Download         Length: 234 bp

>AT179917 NZ_CP084899:1270598-1270664 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References