Detailed information of TA system TA179912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4386847..4387667
• Replicon: chromosome
• Accession: NZ_CP063983
• Organism: Escherichia coli strain 25DN

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: IR210_RS21015
• Protein ID: WP_001054379.1
• Coordinates: 4386847..4387104 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: IR210_RS21020
• Protein ID: WP_194446065.1
• Coordinates: 4387116..4387667 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IR210_RS20995	4382395..4383375	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
IR210_RS21000	4383958..4385001	-	1044	WP_001363826.1	hypothetical protein	-
IR210_RS21005	4385127..4386273	+	1147	Protein_4117	IS3-like element ISEc52 family transposase	-
IR210_RS21010	4386306..4386470	+	165	Protein_4118	GNAT family N-acetyltransferase	-
IR210_RS21015	4386847..4387104	+	258	WP_001054379.1	YjhX family toxin	Toxin
IR210_RS21020	4387116..4387667	+	552	WP_194446065.1	N-acetyltransferase	Antitoxin
IR210_RS21025	4387719..4388465	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
IR210_RS21030	4388593..4388853	+	261	WP_000077645.1	hypothetical protein	-
IR210_RS21035	4388891..4389007	+	117	Protein_4123	VOC family protein	-
IR210_RS21040	4389252..4390373	+	1122	WP_000010833.1	M42 family metallopeptidase	-
IR210_RS21045	4390370..4390648	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
IR210_RS21050	4390660..4391973	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4377048..4395888	18840

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T179912 WP_001054379.1 NZ_CP063983:4386847-4387104 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T179912 NZ_CP084899:c246239-245961 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20386.40 Da
• Isoelectric Point: 6.5657

>AT179912 WP_194446065.1 NZ_CP063983:4387116-4387667 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYRGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT179912 NZ_CP084899:c246502-246242 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Toxin

• AlphaFold DB: B6I030