179904

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2998436..2998907 Replicon chromosome
Accession NZ_CP063983
Organism Escherichia coli strain 25DN

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag IR210_RS14435 Protein ID WP_001303511.1
Coordinates 2998629..2998907 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag IR210_RS14430 Protein ID WP_001302048.1
Coordinates 2998436..2998627 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR210_RS14385 2993685..2993903 - 219 WP_000209148.1 DUF4014 family protein -
IR210_RS14390 2993936..2994148 - 213 WP_000072553.1 hypothetical protein -
IR210_RS14395 2994254..2994676 - 423 Protein_2826 DUF977 family protein -
IR210_RS14400 2994692..2995462 - 771 WP_000450998.1 DUF1627 domain-containing protein -
IR210_RS14405 2995484..2996230 - 747 WP_000788950.1 ATP-binding protein -
IR210_RS14410 2996237..2997199 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
IR210_RS14415 2997222..2997647 - 426 WP_000693943.1 Rha family transcriptional regulator -
IR210_RS14420 2997644..2997946 - 303 WP_001556930.1 transcriptional regulator -
IR210_RS14425 2998044..2998415 + 372 WP_194445930.1 hypothetical protein -
IR210_RS14430 2998436..2998627 + 192 WP_001302048.1 hypothetical protein Antitoxin
IR210_RS14435 2998629..2998907 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IR210_RS14440 2999199..2999351 + 153 WP_000380313.1 DUF1391 family protein -
IR210_RS14445 2999363..2999701 + 339 WP_000394541.1 hypothetical protein -
IR210_RS14450 2999690..2999956 - 267 WP_012601410.1 hypothetical protein -
IR210_RS14455 3000460..3000648 + 189 WP_000449175.1 cell division inhibitor -
IR210_RS14460 3000645..3000833 + 189 WP_000199475.1 DUF1482 family protein -
IR210_RS14465 3000926..3003364 + 2439 WP_000102132.1 exonuclease -
IR210_RS14470 3003426..3003695 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2980901..3008090 27189


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T179904 WP_001303511.1 NZ_CP063983:2998629-2998907 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T179904 NZ_CP084898:c3174619-3174323 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT179904 WP_001302048.1 NZ_CP063983:2998436-2998627 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT179904 NZ_CP084898:c3174321-3173926 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
AlphaFold DB A0A829CTP0

References