Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2676901..2677484 Replicon chromosome
Accession NZ_CP063982
Organism Orrella daihaiensis strain f23

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DHf2319_RS12360 Protein ID WP_243478661.1
Coordinates 2677143..2677484 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DHf2319_RS12355 Protein ID WP_243478660.1
Coordinates 2676901..2677143 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DHf2319_RS12330 (DHf2319_12595) 2672280..2673164 - 885 WP_243478656.1 peptide chain release factor N(5)-glutamine methyltransferase -
DHf2319_RS12335 (DHf2319_12600) 2673115..2674197 - 1083 WP_243478657.1 peptide chain release factor 1 -
DHf2319_RS12340 (DHf2319_12605) 2674307..2675581 - 1275 WP_243478658.1 glutamyl-tRNA reductase -
DHf2319_RS12350 (DHf2319_12615) 2676101..2676805 + 705 WP_243478659.1 NYN domain-containing protein -
DHf2319_RS12355 (DHf2319_12620) 2676901..2677143 + 243 WP_243478660.1 PbsX family transcriptional regulator Antitoxin
DHf2319_RS12360 (DHf2319_12625) 2677143..2677484 + 342 WP_243478661.1 endoribonuclease MazF Toxin
DHf2319_RS12365 (DHf2319_12630) 2677863..2678006 - 144 WP_243478662.1 hypothetical protein -
DHf2319_RS12370 (DHf2319_12635) 2678023..2678679 + 657 WP_243478663.1 NYN domain-containing protein -
DHf2319_RS12375 (DHf2319_12640) 2678710..2679207 + 498 WP_243478664.1 NYN domain-containing protein -
DHf2319_RS12380 (DHf2319_12645) 2679923..2680261 + 339 WP_243478665.1 type II toxin-antitoxin system RelE/ParE family toxin -
DHf2319_RS12385 (DHf2319_12650) 2680281..2680535 + 255 WP_243480104.1 helix-turn-helix transcriptional regulator -
DHf2319_RS12390 (DHf2319_12655) 2680768..2681385 + 618 WP_243478666.1 LysE family translocator -
DHf2319_RS12395 (DHf2319_12660) 2681555..2681809 + 255 WP_243478667.1 DUF2061 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-109)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12546.49 Da        Isoelectric Point: 9.5338

>T179885 WP_243478661.1 NZ_CP063982:2677143-2677484 [Orrella daihaiensis]
VPKSYIPDAGDIVWLEFDPQAGREQAGHRPALVLSPASYNDKVSLAVCCPLSTKVKGYPFEVEVETGKKTSVVLSDQVKS
LDWRERKAKFKSKISSAQLRQVRENIKALLCIS

Download         Length: 342 bp

>T179885 NZ_CP084898:c246239-245961 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8748.11 Da        Isoelectric Point: 5.7760

>AT179885 WP_243478660.1 NZ_CP063982:2676901-2677143 [Orrella daihaiensis]
MQATIKKWGNSPALRISSSIMEQAQLTVNQAVNINVLKGKVIIEPIAPKNTRLDELLAGITPENIHDEESFGQPVGKEIL

Download         Length: 243 bp

>AT179885 NZ_CP084898:c246502-246242 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References