179884

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParE-CopA/ParE-RHH
Location 373918..374530 Replicon chromosome
Accession NZ_CP063982
Organism Orrella daihaiensis strain f23

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DHf2319_RS01775 Protein ID WP_256462166.1
Coordinates 374240..374530 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name copA Uniprot ID -
Locus tag DHf2319_RS01770 Protein ID WP_243479098.1
Coordinates 373918..374223 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DHf2319_RS01755 (DHf2319_01755) 370884..371195 + 312 WP_243479095.1 type II toxin-antitoxin system HigB family toxin -
DHf2319_RS01760 (DHf2319_01760) 371210..371578 + 369 WP_243479096.1 transcriptional regulator -
DHf2319_RS01765 (DHf2319_01765) 371700..373613 - 1914 WP_243479097.1 phosphomethylpyrimidine synthase ThiC -
DHf2319_RS01770 (DHf2319_01770) 373918..374223 + 306 WP_243479098.1 ribbon-helix-helix domain-containing protein Antitoxin
DHf2319_RS01775 (DHf2319_01775) 374240..374530 + 291 WP_256462166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DHf2319_RS01780 (DHf2319_01780) 374559..375056 + 498 WP_243479100.1 hypothetical protein -
DHf2319_RS01785 (DHf2319_01785) 375072..376205 - 1134 WP_243479101.1 glutamate 5-kinase -
DHf2319_RS01790 (DHf2319_01790) 376219..377319 - 1101 WP_243479102.1 GTPase ObgE -
DHf2319_RS01795 (DHf2319_01795) 377388..377645 - 258 WP_243479103.1 50S ribosomal protein L27 -
DHf2319_RS01800 (DHf2319_01800) 377671..377982 - 312 WP_243479104.1 50S ribosomal protein L21 -
DHf2319_RS01805 (DHf2319_01805) 378125..379051 + 927 WP_243479965.1 octaprenyl diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-51)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10895.62 Da        Isoelectric Point: 9.6266

>T179884 WP_256462166.1 NZ_CP063982:374240-374530 [Orrella daihaiensis]
MIRLIWTPAATQDLVCLHAFLKQKNPDAAKKAIAAIRAGVRFLEGHPAIGRRVEGMQEQFREWFIDFGGSGYVALYRTEH
ELTTLLAIRHQKEAGY

Download         Length: 291 bp

>T179884 NZ_CP084897:c4590147-4589806 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11599.09 Da        Isoelectric Point: 7.4678

>AT179884 WP_243479098.1 NZ_CP063982:373918-374223 [Orrella daihaiensis]
MSKPYATARQIAPVAVKLDADMKNRLQALAQSRQRTTHWLLKEAVAQFVYREEQHEALRRDALKAWGDYQETGLHISARE
SDEWLAQLEQGHDVAPPKPHV

Download         Length: 306 bp

>AT179884 NZ_CP084897:4590142-4590218 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References