Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-dinJ/YafQ-DinJ |
| Location | 57919..58453 | Replicon | plasmid pAR_0780 |
| Accession | NZ_CP063981 | ||
| Organism | Enterococcus faecalis strain AR_0780 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | ISN59_RS13225 | Protein ID | WP_048948955.1 |
| Coordinates | 58178..58453 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | R3H6P0 |
| Locus tag | ISN59_RS13220 | Protein ID | WP_002369771.1 |
| Coordinates | 57919..58185 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ISN59_RS13175 (ISN59_13120) | 53380..53541 | + | 162 | WP_002399271.1 | hypothetical protein | - |
| ISN59_RS13180 (ISN59_13125) | 53538..54323 | + | 786 | WP_002387611.1 | replication-relaxation family protein | - |
| ISN59_RS13185 (ISN59_13130) | 54329..54817 | + | 489 | WP_002404733.1 | hypothetical protein | - |
| ISN59_RS13190 (ISN59_13135) | 55410..55676 | + | 267 | WP_126266275.1 | hypothetical protein | - |
| ISN59_RS13195 (ISN59_13140) | 55709..56209 | + | 501 | WP_002360775.1 | DnaJ domain-containing protein | - |
| ISN59_RS13200 | 56346..56471 | + | 126 | WP_229023520.1 | DUF3850 domain-containing protein | - |
| ISN59_RS13205 (ISN59_13150) | 56547..56963 | + | 417 | WP_126266276.1 | single-stranded DNA-binding protein | - |
| ISN59_RS13210 (ISN59_13155) | 56987..57571 | + | 585 | WP_126266277.1 | thermonuclease family protein | - |
| ISN59_RS13215 (ISN59_13160) | 57568..57816 | + | 249 | WP_126266278.1 | alpha-glucosidase | - |
| ISN59_RS13220 (ISN59_13165) | 57919..58185 | + | 267 | WP_002369771.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| ISN59_RS13225 (ISN59_13170) | 58178..58453 | + | 276 | WP_048948955.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| ISN59_RS13230 (ISN59_13175) | 59256..59441 | + | 186 | WP_002365983.1 | hypothetical protein | - |
| ISN59_RS13235 (ISN59_13180) | 59426..59617 | + | 192 | WP_002399282.1 | DpnD/PcfM family protein | - |
| ISN59_RS13240 (ISN59_13185) | 59641..60192 | + | 552 | WP_126263907.1 | hypothetical protein | - |
| ISN59_RS13245 (ISN59_13190) | 60327..61106 | + | 780 | WP_126266279.1 | Cas9 inhibitor AcrIIA9 family protein | - |
| ISN59_RS13250 (ISN59_13195) | 61106..62449 | + | 1344 | WP_126267491.1 | PcfJ domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | erm(A) / optrA / fexA | prgB/asc10 | 1..65096 | 65096 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10718.55 Da Isoelectric Point: 9.6918
>T179883 WP_048948955.1 NZ_CP063981:58178-58453 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKDVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR
MLEIFYTNQFKKDFKKAKKQGKNLEKLKDVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR
Download Length: 276 bp
>T179883 NZ_CP084897:c4543583-4543326 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9804.15 Da Isoelectric Point: 4.4791
>AT179883 WP_002369771.1 NZ_CP063981:57919-58185 [Enterococcus faecalis]
MATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA
MATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA
Download Length: 267 bp
>AT179883 NZ_CP084897:c4543314-4542769 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|