Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3606347..3607325 Replicon chromosome
Accession NZ_CP063975
Organism Bacillus cereus strain N435-1

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag IP614_RS18555 Protein ID WP_000624978.1
Coordinates 3606347..3607084 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag IP614_RS18560 Protein ID WP_000237818.1
Coordinates 3607197..3607325 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IP614_RS18535 3601990..3602772 + 783 WP_016117925.1 class I SAM-dependent methyltransferase -
IP614_RS18540 3602930..3604615 - 1686 WP_043307200.1 alpha-keto acid decarboxylase family protein -
IP614_RS18545 3604723..3605205 + 483 WP_000191888.1 MarR family winged helix-turn-helix transcriptional regulator -
IP614_RS18550 3605372..3606109 + 738 WP_242784773.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
IP614_RS18555 3606347..3607084 + 738 WP_000624978.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
IP614_RS18560 3607197..3607325 + 129 WP_000237818.1 hypothetical protein Antitoxin
IP614_RS18565 3607398..3607631 + 234 WP_242784774.1 stage II sporulation protein SB -
IP614_RS18570 3607593..3607982 - 390 WP_000713864.1 YxeA family protein -
IP614_RS18575 3608193..3609662 + 1470 WP_000287545.1 beta-Ala-His dipeptidase -
IP614_RS18580 3609909..3610718 + 810 WP_000664547.1 papain-like cysteine protease family protein -
IP614_RS18585 3610744..3611346 + 603 WP_000517262.1 hypothetical protein -
IP614_RS18590 3611588..3611839 - 252 WP_000827560.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28325.07 Da        Isoelectric Point: 8.2998

>T179862 WP_000624978.1 NZ_CP063975:3606347-3607084 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHMEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T179862 NZ_CP084897:c1270016-1269909 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT179862 WP_000237818.1 NZ_CP063975:3607197-3607325 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp

>AT179862 NZ_CP084897:1270064-1270130 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References