179860

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4744483..4745504 Replicon chromosome
Accession NZ_CP063955
Organism Klebsiella aerogenes strain S148-1

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A0G9UXE3
Locus tag IOP81_RS22470 Protein ID WP_032706547.1
Coordinates 4744483..4745058 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A0G9R618
Locus tag IOP81_RS22475 Protein ID WP_015369110.1
Coordinates 4745058..4745504 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOP81_RS22450 4740769..4741071 + 303 WP_046883275.1 hypothetical protein -
IOP81_RS22455 4741143..4741431 + 289 Protein_4397 SymE family type I addiction module toxin -
IOP81_RS22460 4741662..4742699 + 1038 WP_046883274.1 RhuM family protein -
IOP81_RS22465 4742982..4744178 - 1197 WP_042893658.1 hypothetical protein -
IOP81_RS22470 4744483..4745058 - 576 WP_032706547.1 PIN domain-containing protein Toxin
IOP81_RS22475 4745058..4745504 - 447 WP_015369110.1 helix-turn-helix domain-containing protein Antitoxin
IOP81_RS22480 4745715..4746722 + 1008 WP_042893659.1 zinc-binding alcohol dehydrogenase family protein -
IOP81_RS22485 4746723..4747025 + 303 WP_238984208.1 putative quinol monooxygenase -
IOP81_RS22490 4747183..4748232 + 1050 WP_032709443.1 NAD(P)-dependent alcohol dehydrogenase -
IOP81_RS22495 4748229..4749182 - 954 WP_125992421.1 helix-turn-helix domain-containing protein -
IOP81_RS22500 4749204..4749983 - 780 WP_045362969.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

SinI-like, DNA-binding domain

(79-126)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21688.29 Da        Isoelectric Point: 6.2900

>T179860 WP_032706547.1 NZ_CP063955:c4745058-4744483 [Klebsiella aerogenes]
MRHSPYPVILDACVLYPARLRDLLMHLGIAGLYQPKWSRFIHDEWCRNLLINRPDIAPEALRRTVDLMNAALPDANVTGF
AGLINGLVLPDPDDRHVLAAAIRAKAEIIVTLNHKDFPAESLLPFEIETLHPDVFISDLFDLNHALALEAVRRQRQSLKH
PPMTVDEFLEMLLKQGLPMTVKELANYQYAI

Download         Length: 576 bp

>T179860 NZ_CP084897:c262893-262552 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16699.26 Da        Isoelectric Point: 6.2257

>AT179860 WP_015369110.1 NZ_CP063955:c4745504-4745058 [Klebsiella aerogenes]
MTKLNLPDPLESELAQRGQRELAAYLSTHLETQRIAIVGEDDKTHTIELPTSALTMLMEILGELACGNAVQIVPVHAELT
TQEAANILNVSRPHMVKLLEARKLPFHKTGRHRRVLFADLMEYKKRREQESLDAMQALADQAQDLGMY

Download         Length: 447 bp

>AT179860 NZ_CP084897:c263231-262914 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G9UXE3

Antitoxin

Source ID Structure
AlphaFold DB A0A0G9R618

References