Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4551539..4552170 Replicon chromosome
Accession NZ_CP063955
Organism Klebsiella aerogenes strain S148-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag IOP81_RS21630 Protein ID WP_015703741.1
Coordinates 4551895..4552170 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag IOP81_RS21625 Protein ID WP_015703740.1
Coordinates 4551539..4551898 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOP81_RS21600 4547796..4548740 + 945 WP_015703735.1 nickel ABC transporter permease subunit NikB -
IOP81_RS21605 4548737..4549570 + 834 WP_015369278.1 nickel ABC transporter permease subunit NikC -
IOP81_RS21610 4549570..4550334 + 765 WP_032715258.1 nickel import ATP-binding protein NikD -
IOP81_RS21615 4550331..4551122 + 792 WP_059444461.1 nickel import ATP-binding protein NikE -
IOP81_RS21620 4551110..4551511 + 402 WP_020077744.1 nickel-responsive transcriptional regulator NikR -
IOP81_RS21625 4551539..4551898 - 360 WP_015703740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IOP81_RS21630 4551895..4552170 - 276 WP_015703741.1 type II toxin-antitoxin system HicA family toxin Toxin
IOP81_RS21635 4552567..4553580 + 1014 WP_015369274.1 magnesium transporter -
IOP81_RS21640 4553621..4554814 - 1194 WP_242814276.1 NAD(P)/FAD-dependent oxidoreductase -
IOP81_RS21645 4555045..4556541 + 1497 WP_015369272.1 inorganic phosphate transporter PitA -
IOP81_RS21650 4556607..4556942 - 336 WP_015703743.1 universal stress protein UspB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T179859 WP_015703741.1 NZ_CP063955:c4552170-4551895 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T179859 NZ_CP084897:252301-252699 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT179859 WP_015703740.1 NZ_CP063955:c4551898-4551539 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT179859 NZ_CP084897:252005-252298 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FNK6

References