Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3978960..3979617 Replicon chromosome
Accession NZ_CP063955
Organism Klebsiella aerogenes strain S148-1

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag IOP81_RS18735 Protein ID WP_015369792.1
Coordinates 3978960..3979370 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag IOP81_RS18740 Protein ID WP_015369791.1
Coordinates 3979351..3979617 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOP81_RS18715 3974959..3976692 - 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -
IOP81_RS18720 3976698..3977411 - 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IOP81_RS18725 3977434..3978330 - 897 WP_015703420.1 site-specific tyrosine recombinase XerD -
IOP81_RS18730 3978431..3978952 + 522 WP_015369793.1 flavodoxin FldB -
IOP81_RS18735 3978960..3979370 - 411 WP_015369792.1 protein YgfX Toxin
IOP81_RS18740 3979351..3979617 - 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
IOP81_RS18745 3979841..3980824 + 984 WP_032712495.1 tRNA-modifying protein YgfZ -
IOP81_RS18750 3980923..3981582 - 660 WP_008806429.1 hemolysin III family protein -
IOP81_RS18755 3981747..3982058 - 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
IOP81_RS18760 3982109..3982843 + 735 WP_015703423.1 MurR/RpiR family transcriptional regulator -
IOP81_RS18765 3982957..3984390 + 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T179857 WP_015369792.1 NZ_CP063955:c3979370-3978960 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T179857 NZ_CP084896:c4590147-4589806 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT179857 WP_015369791.1 NZ_CP063955:c3979617-3979351 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179857 NZ_CP084896:4590142-4590218 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References