Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2273584..2274323 Replicon chromosome
Accession NZ_CP063955
Organism Klebsiella aerogenes strain S148-1

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H3G0L6
Locus tag IOP81_RS10570 Protein ID WP_015705365.1
Coordinates 2273584..2274069 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag IOP81_RS10575 Protein ID WP_015705366.1
Coordinates 2274057..2274323 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOP81_RS10550 2269131..2270201 - 1071 WP_015705361.1 mannonate dehydratase -
IOP81_RS10555 2270462..2270620 + 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
IOP81_RS10560 2270677..2271777 - 1101 WP_242814557.1 NADH:flavin oxidoreductase/NADH oxidase -
IOP81_RS10565 2271896..2273512 - 1617 WP_242814558.1 FAD-NAD(P)-binding protein -
IOP81_RS10570 2273584..2274069 - 486 WP_015705365.1 GNAT family N-acetyltransferase Toxin
IOP81_RS10575 2274057..2274323 - 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
IOP81_RS10580 2274596..2275831 + 1236 WP_032711619.1 MFS transporter -
IOP81_RS10585 2275875..2276372 - 498 WP_032711620.1 heme-binding protein -
IOP81_RS10590 2276468..2277085 - 618 WP_032705773.1 response regulator -
IOP81_RS10595 2277085..2278404 - 1320 WP_042897499.1 ATP-binding protein -
IOP81_RS10600 2278401..2278988 - 588 WP_046883610.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17603.25 Da        Isoelectric Point: 8.8590

>T179848 WP_015705365.1 NZ_CP063955:c2274069-2273584 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAYHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T179848 NZ_CP084896:c2917166-2916831 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT179848 WP_015705366.1 NZ_CP063955:c2274323-2274057 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT179848 NZ_CP084896:c2917414-2917166 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3G0L6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References