Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 990691..991310 Replicon chromosome
Accession NZ_CP063955
Organism Klebsiella aerogenes strain S148-1

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag IOP81_RS04560 Protein ID WP_015367918.1
Coordinates 990691..990909 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag IOP81_RS04565 Protein ID WP_015367917.1
Coordinates 990936..991310 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOP81_RS04530 986764..987024 + 261 WP_015367923.1 type B 50S ribosomal protein L31 -
IOP81_RS04535 987027..987167 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
IOP81_RS04540 987164..987874 - 711 WP_015704607.1 GNAT family protein -
IOP81_RS04545 987977..989431 + 1455 WP_049033189.1 PLP-dependent aminotransferase family protein -
IOP81_RS04550 989406..989870 - 465 WP_042893755.1 YlaC family protein -
IOP81_RS04555 989996..990559 - 564 WP_020079452.1 maltose O-acetyltransferase -
IOP81_RS04560 990691..990909 - 219 WP_015367918.1 HHA domain-containing protein Toxin
IOP81_RS04565 990936..991310 - 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
IOP81_RS04570 991783..994929 - 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit AcrB -
IOP81_RS04575 994952..996151 - 1200 WP_047038885.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T179847 WP_015367918.1 NZ_CP063955:c990909-990691 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T179847 NZ_CP084896:2783528-2783857 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT179847 WP_015367917.1 NZ_CP063955:c991310-990936 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT179847 NZ_CP084896:2783190-2783507 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References