Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 349644..350336 Replicon chromosome
Accession NZ_CP063955
Organism Klebsiella aerogenes strain S148-1

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag IOP81_RS01610 Protein ID WP_098947915.1
Coordinates 349995..350336 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag IOP81_RS01605 Protein ID WP_242814336.1
Coordinates 349644..349970 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOP81_RS01575 345013..346101 + 1089 WP_193136381.1 hypothetical protein -
IOP81_RS01580 346183..347073 + 891 WP_193136380.1 YfjP family GTPase -
IOP81_RS01585 347110..347463 - 354 WP_151085329.1 hypothetical protein -
IOP81_RS01590 347783..348472 + 690 WP_193136379.1 hypothetical protein -
IOP81_RS01595 348696..349142 + 447 WP_186932050.1 antirestriction protein -
IOP81_RS01600 349153..349629 + 477 WP_098947919.1 DNA repair protein RadC -
IOP81_RS01605 349644..349970 + 327 WP_242814336.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IOP81_RS01610 349995..350336 + 342 WP_098947915.1 TA system toxin CbtA family protein Toxin
IOP81_RS01615 350452..351285 + 834 WP_080851711.1 DUF4942 domain-containing protein -
IOP81_RS01620 351912..353636 + 1725 WP_193136376.1 retron Ec67 family RNA-directed DNA polymerase/endonuclease -
IOP81_RS01625 354186..354956 + 771 WP_095427332.1 DUF5677 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12874.80 Da        Isoelectric Point: 8.4982

>T179846 WP_098947915.1 NZ_CP063955:349995-350336 [Klebsiella aerogenes]
MKTIPATTQRAAKSCPSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGF
NCQEQSPYLRAVDILRARQATGLLQYRRNTLSL

Download         Length: 342 bp

>T179846 NZ_CP084896:2771993-2773066 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12205.96 Da        Isoelectric Point: 6.3107

>AT179846 WP_242814336.1 NZ_CP063955:349644-349970 [Klebsiella aerogenes]
MPLTDAIQWGLQRSVTPCFGARLVQEGNRLHYLADRASITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAYCVT
LYHNDLTCEADTCGSCGHVYIVIYPTQR

Download         Length: 327 bp

>AT179846 NZ_CP084896:2773059-2773430 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References