Detailed information of TA system TA179845

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5265783..5267464
• Replicon: chromosome
• Accession: NZ_CP063954
• Organism: Klebsiella variicola strain S129-1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: IOD50_RS25265
• Protein ID: WP_194394842.1
• Coordinates: 5266547..5267464 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: IOD50_RS25260
• Protein ID: WP_117107357.1
• Coordinates: 5265783..5266541 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOD50_RS25245	5261246..5261932	-	687	WP_008807260.1	sel1 repeat family protein	-
IOD50_RS25250	5262550..5264697	-	2148	WP_012543160.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
IOD50_RS25255	5264970..5265698	+	729	WP_008807258.1	response regulator transcription factor	-
IOD50_RS25260	5265783..5266541	+	759	WP_117107357.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
IOD50_RS25265	5266547..5267464	+	918	WP_194394842.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
IOD50_RS25270	5267589..5268596	-	1008	WP_023339423.1	carbohydrate kinase family protein	-
IOD50_RS25275	5268671..5269612	-	942	WP_064144599.1	ABC transporter substrate-binding protein	-
IOD50_RS25280	5269643..5270641	-	999	WP_023296904.1	ribose ABC transporter permease	-
IOD50_RS25285	5270638..5272158	-	1521	WP_194394841.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34703.08 Da
• Isoelectric Point: 5.4707

>T179845 WP_194394842.1 NZ_CP063954:5266547-5267464 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGINAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T179845 NZ_CP084896:c2094680-2094429 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28683.04 Da
• Isoelectric Point: 10.2152

>AT179845 WP_117107357.1 NZ_CP063954:5265783-5266541 [Klebsiella variicola]
MSSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDRYRVLLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT179845 NZ_CP084896:c2094432-2094178 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA