Detailed information of TA system TA179830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2146202..2147790
• Replicon: chromosome
• Accession: NZ_CP063954
• Organism: Klebsiella variicola strain S129-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IOD50_RS10240
• Protein ID: WP_194394605.1
• Coordinates: 2146468..2147790 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A1F2MCN9
• Locus tag: IOD50_RS10235
• Protein ID: WP_008804920.1
• Coordinates: 2146202..2146468 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOD50_RS10210	2141352..2142275	+	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-
IOD50_RS10215	2142256..2143410	-	1155	WP_023322603.1	FAD-dependent urate hydroxylase HpxO	-
IOD50_RS10220	2143756..2145135	+	1380	WP_012968246.1	purine permease	-
IOD50_RS10225	2145113..2145613	+	501	WP_008804922.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
IOD50_RS10230	2145610..2145936	+	327	WP_008804921.1	hydroxyisourate hydrolase	-
IOD50_RS10235	2146202..2146468	+	267	WP_008804920.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IOD50_RS10240	2146468..2147790	+	1323	WP_194394605.1	type II toxin-antitoxin system HipA family toxin	Toxin
IOD50_RS10245	2147807..2149099	-	1293	WP_012968243.1	glycoside hydrolase family 10 protein	-
IOD50_RS10250	2149232..2150236	-	1005	WP_194394604.1	type 1 fimbrial protein	-
IOD50_RS10255	2150224..2152725	-	2502	WP_194394603.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 48795.14 Da
• Isoelectric Point: 7.9109

>T179830 WP_194394605.1 NZ_CP063954:2146468-2147790 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIASARRTLPADFSAHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T179830 NZ_CP084895:c4590148-4589807 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.30 Da
• Isoelectric Point: 8.5912

>AT179830 WP_008804920.1 NZ_CP063954:2146202-2146468 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT179830 NZ_CP084895:4590143-4590219 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin

• AlphaFold DB: A0A1F2MCN9