Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1665926..1666545 Replicon chromosome
Accession NZ_CP063942
Organism Klebsiella quasipneumoniae strain BS418

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag ISA61_RS07705 Protein ID WP_002892050.1
Coordinates 1665926..1666144 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag ISA61_RS07710 Protein ID WP_002892066.1
Coordinates 1666171..1666545 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA61_RS07670 1661969..1662232 + 264 WP_004204754.1 type B 50S ribosomal protein L31 -
ISA61_RS07675 1662232..1662372 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
ISA61_RS07680 1662369..1663067 - 699 WP_004204753.1 GNAT family N-acetyltransferase -
ISA61_RS07685 1663168..1664625 + 1458 WP_049117056.1 PLP-dependent aminotransferase family protein -
ISA61_RS07690 1664594..1665064 - 471 WP_004204751.1 YlaC family protein -
ISA61_RS07695 1665107..1665229 + 123 WP_032426076.1 hypothetical protein -
ISA61_RS07700 1665201..1665767 - 567 WP_004204750.1 maltose O-acetyltransferase -
ISA61_RS07705 1665926..1666144 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
ISA61_RS07710 1666171..1666545 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
ISA61_RS07715 1667030..1670176 - 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit -
ISA61_RS07720 1670199..1671392 - 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T179754 WP_002892050.1 NZ_CP063942:c1666144-1665926 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T179754 NZ_CP084893:c1270016-1269909 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT179754 WP_002892066.1 NZ_CP063942:c1666545-1666171 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT179754 NZ_CP084893:1270064-1270130 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References